Microdosing LSD vs Microdosing Mushrooms

Eden Loi · June 26th, 2018

Microdosing LSD vs Psilocybin: what's the difference?

Microdosing is pushing psychedelic use back into the mainstream, breathing new life into the psychedelic conversation. Its benefits for productivity, creativity, and personal growth are rewriting the stereotypical psychedelic image.

In case you are unfamiliar with the term, microdosing refers to ingesting a small, sub perceptual amount of a psychedelic substance. The revolutionary thing about microdosing is the control it gives to the user. Instead of taking a potentially unpredictable higher dose, microdosing allows you to guide your own psychedelic experience. You decide on the amount of the dose, the frequency of doses, and the duration of the whole process. Microdosing is a tool for self-exploration and control, and it works best when paired with intentional curiosity.

Considering the amount of control one has over their psychedelic experience when microdosing, let’s tackle the first significant choice you will face when starting out—what substance do you want to use? While there are plenty of psychedelics out there to experiment with, this article will focus on psilocybin mushrooms and LSD. Due to their popularity and the amount of existing information surrounding them, LSD and psilocybin are your two most likely choices when looking to microdose.

Listen to what does a world-class fitness coach have to say about the differences between LSD and psilocybin mushrooms for microdosing? Featuring Ben Greenfield or Click here to read the transcript

Consider the vibe

Before weighing the fine details of psilocybin and LSD against each other, it’s a good idea to begin with the most apparent difference between the two: psilocybin mushrooms come from the earth, and LSD from the laboratory. Depending on your outlook, the natural/synthetic difference could be a good thing or a bad thing.

Some people prefer to ingest natural psychedelic substances instead of synthetic. It’s a valid perspective. The preference for natural over synthetic could be for ethical, aesthetic, or any number of other reasons. The thought of ingesting an extremely potent, psychoactive, synthesized substance puts some people off. A person could theoretically hand you a tab of anything, made by anyone. Psilocybin mushrooms, on the other hand, grow naturally and have been used in sacred ritualistic practices for millennia. This point of view may regard LSD as more of a stereotypical “drug” while seeing mushrooms as something like an intense cousin of marijuana. If taking psilocybin mushrooms instead of LSD would prevent you from feeling any guilt or fear, then go for the mushrooms.

Others, however, may prefer the synthetic nature of LSD to naturally growing mushrooms. LSD has been tinkered with and fine-tuned in labs by chemists for the better half of a century, while psilocybin mushrooms still grow in piles of shit and resemble other mushrooms that are poisonous to ingest. This perspective prefers the “clean” feel and experience of LSD over the earthy, almost ubiquitously disliked flavor of dried mushrooms. LSD is streamlined to enter your system and get to work. Mushrooms are fungi that happen to trip you out. For people who don’t mind the synthetic nature of LSD and are looking for something cleaner and, for lack of a better term, a more pharmacological experience, LSD is the way to go.

Ultimately though, these differences could be repudiated by a single experience with either substance. If you’ve never tried psilocybin or LSD and are drawn to one over the other, for whatever reason, start there. If you like it, good. If not, try the other. Even if you like your first choice, you could try the other anyway. Again, microdosing is about curiosity and control.

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Scissors? Pestle? Nittier, grittier considerations

Another considerable difference between psilocybin and LSD is the dosage, form, and concentration of each, and how those factors affect the preparation of a microdose.

The process of divvying up a microdose from an LSD tab is relatively straightforward and probably easier than doing it with mushrooms. You can cut up the tab into smaller pieces or dilute it into a larger volume of water, which then can be cleanly divided.

Want to know for sure if your LSD is actually LSD? Get yourself a testing kit to make sure you’re microdosing safely.

If you want consistent amounts of mushrooms for microdosing, the best way is to grind them up into a powder, and then weigh and dole the powder out into capsules. This takes a fair bit of work, requiring some pestle or grinder, capsules, and preferably, a scale. The psilocybin in mushrooms concentrates at different levels between the mushroom cap and the stem, so eyeballing an amount will be inconsistent. Read more about how to prepare psilocybin mushrooms for microdosing here.

In terms of acquiring these substances, your options for LSD include the potential legal alternative 1P-LSD, whereas your options for psilocybin mushrooms involve purchasing legal psilocybin truffles online, growing your own mushrooms, or attending a psilocybin retreat where it’s legal. See our full guides on the legality of LSD analogs and the legality of psilocybin mushrooms for more.

And if you’re ready to easily start growing your own mushrooms from home, check out Third Wave’s How to Grow Mushrooms Course and Grow Kit.

Difference in experience

If you are wondering about the difference in experience between LSD and mushrooms when microdosing, their natural/synthetic difference illustrates it quite aptly. If I could describe each with a word, I’d say that mushrooms provide an “earthy” experience while LSD provides a “crisp” one.

Mushrooms tend to dissolve the ego by immersing the user in their surroundings, which can be real or imagined. They promote deep introspection and meditation. It’s likely you will feel a deeper connection to, and understanding of, the ancient rituals that used mushrooms. Think grounded feelings, tactile undulations. Even with a microdose, you may still experience the sensation of being plunged into your mushroom trip.

LSD will dissolve the ego through the sheer clarity of experience. Sounds, colors, and interactions will seem to happen smoothly and without your involvement. You will feel at home both on a walk in the woods and at a coffee shop in the city. It’s flexible, forgiving, and uplifting. LSD feels like something designed to improve you. If you plunge into the depths of mushrooms, you emerge from the surface with LSD.

How are you going to spend your day when microdosing? If you have professional work to do, if you will be socializing and interacting with strangers or colleagues, or if you will be in busy, populated environments, LSD may be the better choice. However, if you have an open day and open space, and are seeking some introspection and solitude, mushrooms are perfect. That’s not to say that specific experiences must pair with a specific substance, but from anecdotal reports and personal experience, each has its own better environment. Keep in mind, too, that LSD and mushrooms have different durations. The effects of LSD last anywhere from six to 10 hours; psilocybin, from four to eight hours.

Picking A Favorite Child

Ultimately, recommending LSD or psilocybin mushrooms for microdosing is like asking which child a parent likes most. The answer will come with all sorts of qualifications and contingencies, will assert that all are equally excellent, but will secretly harbor the fact that there is, in fact, a favorite.

For me, I prefer microdosing with LSD. It’s easier to manage doses, feels cleaner, and the manageable, productive experience is more aligned with how I view microdosing. LSD, in my opinion, is more suited for use as a self-improvement medicine that puts you in control.

But I’ve also tried microdosing with mushrooms, and my experience was wonderful. In fact, one of my favorite psychedelic experiences happened while microdosing mushrooms, in which a friend and I, for a few hours, tapped into some other-dimensional hacky sack skills. It was an objectively impressive upgrade in capabilities, and I should add one last note that I believe microdosing mushrooms has serious potential to improve physical and athletic performance.

Hopefully, this short guide has illustrated some differences between microdosing LSD and psilocybin. You can find a lot more by checking out our dedicated articles on microdosing psilocybin mushrooms and LSD.

The best guide will forever be your own experience, so stay curious and love what you find. Good luck!

Looking for more information about microdosing? Interested but don’t know where to start? Sign up to our pioneering microdosing course to gain access to exclusive resources and join a community of like-minded microdosers!

Want to easily grow mushrooms at home?

Third Wave’s Mushrooms Grow Kit and Course turn the daunting task of cultivating mushrooms into a simple one.

Our in-depth guide and step-by-step videos will have you harvesting your own home-grown mushrooms in no time.

Reader Interactions


    • AvatarHaya says

      I did a google search of “microdosing nutmeg” and found the following information:





  1. AvatarE Ray says

    I wonder what kind of dose the author is using. Someone on a true microdose should not experience psychedelic effects.

  2. AvatarDale says

    It is sad that non of these seems to suit me.
    Lsd leaves me out of body strength during a day and lack of sleep during a night.
    Shrooms give me bad depression the day after microdose.
    I’m gutted.

    • AvatarJameson says

      Have you tried a dosage higher than a micro dose? The reason I ask is those types of experiences at a higher dosage can be much different. The next day the mind is a little cloudy and drained but the type of experience can break down unique barriers. What type of environment are you in when you are medicating? Have you ever tried using cannabis before and during a mushroom setting? How are you taking your medicine? Have you ever tried using OJ before and during on mushrooms?

      • AvatarDale says

        I tried higher doses too. Lsd gives me bad trippy feeling and confusion also no sleep at all the following night.
        Shrooms are nice on the microdose day, but the day after the hell of deep dark depression breaks loose in my head and I wish I never took them.

    • Avatarpreston says

      From what Ive read online: LSD has a chemical structure similar to serotonin. Im not sure about psilocybin, but it’s in the same group (Tryptamines) which include neurotransmitters. I also read where the racetams use up some of the neurotransmitter chemicals and can leave someone feeling depressed the day after – it is suggested to use choline (the precursor to Acetylcholine), which choline also stacks well with racetams. My guess is that LSD is additive / uses fake serotonin, but the psilocybin may work differently and may be using up other neurotransmitter chemicals – be it dopamine or serotonin. All that said, but you could try adding choline, dopamine or serotonin the day after microdosing the shrooms and see if one of them reverses the depression.

  3. AvatarNewSjamaan says

    The dark depression are maybe already long time been a part of you, and they come to the surface because of the drugs.

    Do you have had other help or therapy before?
    Maybe you need to try a few breathing sessions (good ones will make you high), group therapy, professional counseling, to strengthen your core to undergo the microdosis, sounds fair?

  4. AvatarMax says

    I don’t think this writer likes shrooms a lot. if what he says isn’t common in my research cause I research for months before I take new drugs. for LDS I researched for years before I took it. And my experience with LSD wasn’t crisp at times it was almost too much to handle. And most growers don’t grow in cow shit. In fact I’ve never met one that did

  5. AvatarKiki says

    I wonder if you want to microdose because of mental problems if there is one who’s better. Anyone knows? Depression, anxiety, low self-esteem. I am a sensitive person. I wonder what is best for me to try.

    • Avataraz says

      I have both experiences. I think based on what lsd you microdose, the experience will be different. I’ve got an intense formula and microdosing with that has huge difference with a normal one I have.
      Microdosing with mushrooms for me depends on the strain. Different vibe and mood based on the strain but it’s smoother experience in general.

  6. Avatarbrad dawson says

    just started my first day of microdosing on shrooms, have noticed increased mood, focus, more energy. currently supplementing with spore wellness energy blend, so far so good. will report back

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