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Research chemicals are synthetic or semi-synthetic molecules that are designed specifically to circumvent drug laws. They are created to mimic the effects of prohibited substances. They can often be purchased online, often labelled as ‘Not for Human Consumption’ to minimize the liability of the people selling them. Due to their constantly evolving nature, their relative harms are unknown compared to the substances they intend to mimic.

The most popular research chemicals are substances that mimic popular psychedelics like LSD and MDMA. Here, we’ll run through some well-known research chemicals, and we’ll tell you everything we know about their legality.

Disclaimer: Research chemicals are potentially illegal substances, and we do not encourage or condone the use of these substances where it is against the law. However, we accept that illegal drug use occurs, and believe that offering responsible harm reduction information is imperative to keeping people safe. For that reason, this guide is designed to ensure the safety of those who decide to use the substances. We do not encourage using these drugs outside of a legal or traditional context.

1P-LSD

1-propionyl-lysergic acid diethylamide, or 1P-LSD, is one of the most popular research chemicals in the world at the moment, and is a common choice for microdosers who don’t want to break the law.

Its chemical structure is very similar to that of LSD, with a small propionyl group added to the indole ring. According to various threads and forums online, the psychological effects of 1P-LSD are almost indistinguishable from LSD.

1P-LSD probably acts as a prodrug to LSD, and is most likely quickly metabolized into LSD in the body.

LEGALITY

Several countries have specifically banned 1P-LSD, including Sweden and Switzerland.

Other countries have banned analogues of LSD, which 1P-LSD falls under. Examples are the US Federal Analogue Act, and Latvia’s amendment on tryptamine derivatives. However, we have heard of no cases of people being prosecuted for 1P-LSD possession under these laws.

The UK’s Psychoactive Substances Act means that 1P-LSD is illegal to sell, although you can still possess it. There have been no cases of people being charged for anything related to 1P-LSD.

1P-LSD is legal to purchase and possess in Germany and Canada. If your country doesn’t have a specific regulation against 1P-LSD, or LSD analogues, then it is probably legal to purchase and possess – but always check your local laws. We don’t recommend illegal activities.

2C-B

2,5-dimethoxy-4-bromophenethylamine, or 2C-B, was designed by Alexander Shulgin in his research of phenethylamines. 2C-B shares structural similarities to mescaline (peyote), but possesses slightly different effects.

Its effects include a body high similar to that of MDMA, but combines the empathogenic properties of MDMA with the psychedelic visuals of LSD.

It is considered one of the more mild psychedelics, and is relatively short-lasting.

LEGALITY

2C-B is prohibited in most countries, due to its inclusion in the UN Commission on Narcotic Drugs in 2001. It’s best to avoid this substance to stay on the right side of the law.

AL-LAD

6-allyl-6-nor-lysergic acid diethylamide, or AL-LAD (also known as Aladdin), is derived from LSD, with the difference being the addition of an allyl group.

Reports suggest that this chemical has similar psychological effects to LSD, although with a shorter duration. It’s apparently less likely to provoke anxiety and has been described as a less intense version of LSD, and the ideal ‘starter psychedelic’.

LEGALITY

In the US, AL-LAD falls into the same legal gray area as 1P-LSD, where possession and supply could potentially be prosecuted under the Federal Analogue Act.

In the UK, AL-LAD was added to the Misuse of Drugs Act and is considered a Schedule I drug.

AL-LAD is also illegal in Sweden, Switzerland and Latvia.

ALD-52

1-Acetyl-N,N-diethyllysergamide, or ALD-52, is a derivative of LSD, with the main difference being the addition of an acetyl group to the indole ring.

The subjective psychological effects on humans are not well established, although they’ve been reported to be similar to those of LSD.

LEGALITY

In the US, ALD-52 falls into the same legal gray area as 1P-LSD, where possession and supply could potentially be prosecuted under the Federal Analogue Act.

In the UK, ALD-52 was added to the Misuse of Drugs Act and is considered a Schedule I drug.

ALD-52 is also illegal in Latvia.

ETH-LAD

6-Ethyl-6-nor-lysergic acid diethylamide, or ETH-LAD, is a derivative of LSD. The main difference between the compounds is an addition of an ethyl group in ETH-LAD.

The subjective effects of ETH-LAD are not well known, although user reports suggest that the effects are somewhat similar to those of LSD.

LEGALITY

In the US, ETH-LAD falls into the same legal gray area as 1P-LSD, where possession and supply could potentially be prosecuted under the Federal Analogue Act.

In the UK, ETH-LAD was added to the Misuse of Drugs Act and is considered a Schedule I drug.

ETH-LAD is also illegal in Sweden, Switzerland and Latvia.

LSZ

Lysergic acid 2,4-dimethylazetidide (also known as Lambda) or LSZ is an LSD derivative created by David Nichols and fellow researchers at Purdue University. It differs from LSD with the addition of an azetidine group.

Its psychological effects are reported to be similar to those of LSD.

LEGALITY

LSZ is illegal in Switzerland and Sweden.

It could possibly fall under the US Federal Analogue Act, although there have been no prosecutions so far.

In the UK, LSZ was added to the Misuse of Drugs Act and is considered a Schedule I drug.

PRO-LAD

6-propyl-6-nor-lysergic acid diethylamide, or PRO-LAD, is a derivative of LSD. Its main difference from LSD is the addition of a propyl group.

The psychological effects of PRO-LAD are relatively unknown, although users report a general similarity to the effects of LSD.

LEGALITY

In the US, PRO-LAD falls into the same legal gray area as 1P-LSD, where possession and supply could potentially be prosecuted under the Federal Analogue Act.

In the UK, PRO-LAD was added to the Misuse of Drugs Act and is considered a Schedule I drug.

PRO-LAD is also illegal in Sweden, Switzerland and Latvia.

4-ACO-DMT

4-AcO-DMT is a designer psychedelic with a similar molecular structure to psilocybin. Like psilocybin, 4-AcO-DMT is thought to be a prodrug of psilocin, and as such its psychedelic effects are nearly indistinguishable from those of psilocybin mushrooms.

There is no known toxicity or addictive potential of 4-AcO-DMT.

LEGALITY

4-AcO-DMT is illegal in the UK, Brazil, Italy and Sweden.

In the US, 4-AcO-DMT may fall under the Federal Analogues Act, which would make its sale illegal.

In most other countries, it is legal to possess 4-AcO-DMT for personal use.

4-HO-MIPT

4-HO-MiPT is a designer psychedelic with structural similarities to psilocin. As such, it produces psychedelic effects that are virtually indistinguishable from psilocybin mushrooms.

There is no known toxicity or addictive potential of 4-HO-MiPT.

LEGALITY

4-HO-MiPT is illegal in Sweden and the UK.

In the US, 4-HO-MiPT could fall under the Federal Analogues Act, which would make its sale illegal.

WHY DO RESEARCH CHEMICALS EXIST?

It might strike you that these substances are all potentially dangerous, considering they haven’t been tested in humans, or used for thousands of years like natural psychedelics have.

The reason they exist in the first place is arguably to explore the psychedelic potential of different substances. But the reason they are popular is because they circumvent some laws. Prohibition is the main source of fuel for these substances.

If psychedelics were legalised, these drugs could be fully tested and people would have access to safe substances.

Prohibition just pushes people to find more and more dangerous ways of exercising their cognitive freedom.

Important Note: This is a constantly-evolving document. If you believe we’re missing something important,please let us know via the contact page.

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Comments

  1. You guys are doing the right thing!! these should be accessible to people who want to use them in scientific manners.

  2. I wish that we could end America’s absurd and enormously destructive “war on drugs” which benefits only drug lords and corrupt, thieving enforcement agencies. we could then devote resources to serious study of entheogens. Instead of discovering safe and effective uses for these substances we are throwing away lives and treasure and missing out on potentially life changing therapies in the fields of mental health and addiction. Now we have an Attorney General who is hostile even to marijuana (only “bad people” use it!). As a person suffering from long term clinical depression and anxiety I am Very interested in microdosing as well as shamanic Journeying. I am extremely frustrated at the legal idiocy that makes it so difficult to obtain and control dosages of entheogens while pushing pharmaceuticals of questionable effectiveness. Also, there is not a lot of info on how the prescription drugs I’m taking interact with these other substances.
    Thanks for the space to rant!

      • Im 51 and recently lost my son to an accidental heroin overdose he was 23 and at this point im severly deppresed ! I dont no what to do other than therapy and hasn’t helped! My shrink said to try psycedelics not sure !
        I did alot of acid in high school! Any suggestions?

        • Hi Jeff,

          I am not a professional therapist, but I have had tremendously healing experiences with mushrooms at a dose range of 3-3.5 grams. I recommend consuming them either at home (especially if you are comfortable there and have positive memories associated there) or in nature – somewhere beautiful where you don’t have to worry about other people interrupting you. Make sure you have everything you need to stay warm and hydrated, and that you have a safe space to be in case you experience any anxiety. Ideally, you would have someone there who knows you well and has experience with psychedelics. If you have someone who is close and would watch over you, but they have no psychedelic experience, they could familiarize themselves with strategies for “trip-sitting” online. I know you said you did acid as a kid, so some of this advice may seem unnecessary, but tripping as an adult with therapeutic or spiritual intentions is very different from adolescent recreational use, and will likely produce an entirely different form of experience. There is an underground network of therapists who use mushrooms, mdma (also possibly a very good option for you), and lsd in conjunction with psychotherapy, but it can be tough to find these people. Good luck my friend. Sorry for your loss.

      • sir i would not suggest going straight into hardcore psychedelics,i would first recommend you look into ketamine infusion therapy.

    • we are a nation of sheep. happy if we have a chicken in the pot. until the sheep rise to take what is theirs nothing happens. sacrifice freedom for security and guess what happens. I wonder who benefits from the drug wars. the opiate scare has created MORE BUSINESS FOR THE HEROIN DEALERS.

      john rayburn
      Williamsburg nm

  3. I’m thankful for people like you interested in objective information and harm reduction. If it weren’t for groups like you, while researching different analogs for molecules like psilocin or DMT, I never would have known that taking them while on an SSRI can kill you from serotonin syndrome. Keep up the good work. You’re saving lives of most types of people who are too afraid to thank you. I’m an idiot, so I couldn’t care less. LOL.
    Thank you.

    • Order 1p lsd from lysergi I’ve taken it from lysergi before it is the exact same thing as really good acid, but it’s lab made and measured…so basically you can trust what you get

    • Do you live in the US? Just wondering because I live in the US and that Federal drug act he was talking about has me a bit worried.

  4. I don’t get why Rogan and other celebrities such as Bed Greenfield have such easy access to these drugs. That talk about doing it as if they have a chemist making it for them. The above information is informative but either I am reading it wrong or it is not telling me how to obtain it. I know how to get blotter from random people who are not trustworthy but that doesn’t sound like the correct path of getting clean safe products. Any suggestions or countries I need to go to obtain ?

    • What don’t you get? How hard is it to network with “the right people” when you are that famous (especially famous for trying stuff like that)?

      Telling you how to get it? Unless this is your first time on the internet, did you really expect them to tell you where to order drugs? Try this thing called Google.

    • That’s incredibly tragic. Thank you for sharing your son’s story, even though I know it must be incredibly painful. Do you know what specific research chemicals, or class of research chemicals your son was taking? The substances listed above are part of a class of substances that are relatively non-toxic and non-addictive. Ideally people would not experiment with these drugs, but some people will continue to do so, and if they know a specific one has caused death, they will be less likely to use it. By sharing the details of what your son took, you could save someone else’s life.

  5. There is absolutely no “safe” way to use research chemicals! My son was a very intelligent young man. He got in some legal trouble with illegal drugs…by the time he was arrested I believe he was already addicted. Once he discovered so-called “research chemicals” he found a way to feed his addiction, “legally.” What no one seems to address is that once you start using drugs as a young adult, you’ve damaged your underdeveloped brain (which continues to develop until about the age of 25). The part of the brain being damaged is the “good decision-making” part. Once we discovered what he was doing, using these “research chemicals,” we finally convinced my son to go into rehab. He went, graduated the program, and stayed clean for a few months. But is addiction took over again. My son died on June 16, 2017, from a “synthetic drug” overdose. He had been using research chemicals for only 18 months. As I mentioned, he WAS a very intelligent young man. He thought he was too smart to overdose. Just like you all. Don’t fool yourself into thinking it couldn’t be you.

    • I know that a million people know have told you this and you dont know me but i am so sorry that this has happened to you. this Research Chemical crap is so destructive. i am lucky that this stuff came out after i graduated high school. the most lucrative part is you can buy this online and can be 10 yrs old. kids that cant find pot to smoke or are drug tested find this junk that is way way worse for you there are herion addicts that quit cold turkey to start doing RC’s. So sorry again

    • I’m sorry for you loss. Just because your son had a bad experience doesn’t mean these cannot be used safely. That’s why we don’t ban caffeine when someone dies from it.

      Might I ask, what drug and at what dosage he took? At least we can make a cautionary tale from the specifics. To apply this to all drugs and dosages would be remiss.

    • Thank you for posting. I hope everyone reading this will truley understand they can loose their lives. I hope you continue to share your story as far and wide across this world that you possibly can. So sorry for your lost. I grieve for the loss of a loved one as well. Thank you again!

    • @Aimee Curran,
      Your comment is quite vague as it does not tell us what drug was responsible for your son’s untimely demise. None of the drugs mentioned in this article can cause an overdose. Nor are any of them addictive.

      • Why Are drugs the only bad thing that can cause harm. No one preaches probation of alcohol when it ruins a life.

        Your son was executing his rights, it’s a shame he didn’t have access to safer alternatives.

  6. I’m sorry for your loss. Just because your son had a bad experience doesn’t mean these cannot be used safely. That’s why we don’t ban caffeine when someone dies from it.

    Might I ask, what drug and at what dosage he took? At least we can make a cautionary tale from the specifics. To apply this to all drugs and dosages would be remiss.

  7. Thank you for posting. I hope everyone reading this will truley understand they can loose their lives. I hope you continue to share your story as far and wide across this world that you possibly can. So sorry for your lost. I grieve for the loss of a loved one as well. Thank you again!

  8. I suffer from ADHD and fractured bones in my wrist that causes severe pain. My Docter took me off my Adderall when she found marijuana in my system. I can barely focus and complete tasks now and have suffered much from memory loss. I quit smoking pot because it makes me paranoid. Is there a legal stimulant to replace the Adderall so I can focus. AlSO THE SEVERE pain in my wrist keeps me depressed and tormented because I can not use my right hand. Is there a legal opioid analog that I CAN order for the severe pain. I have been searching for sources many years but have found none. I don’t want to suffer anymore. I dream to obtain this knowledge to heal myself and others. TEACH ME good medicine.

    • Hello,

      I am really sorry to hear about your condition and I truly wish there was an answer I could give you.

      Unfortunately, due to legal concerns, we cannot offer any information about sourcing here. Your best bet would be to do the research yourself or to consult a doctor.

  9. The current political climate has become increasingly hostile to drugs, especially those that have been defined as Schedule I. In the section addressing 1P-LSD, the author writes:

    Other countries have banned analogues of LSD, which 1P-LSD falls under…However, we have heard of no cases of people being prosecuted for 1P-LSD possession under these laws.

    Have there been one (or more) case in which someone been prosecuted in the US for 1P-LSD (or other research chemicals) possession since this article was originally written in March 2017 a little more than a year ago?

    • I’d stay away from any “pain” relieving research chemicals… as you’re only asking for serious complications and/or death with things like U-4700 and Tianeptine…

  10. Thanks for all you guys do, it’s beyond words the gratitude.
    I would like to know how and if methadone hci interacts w any of these..
    Say for example 4-aco-dmt? Or 1p-lsd? Any risks worth noting?

  11. I’ve had eth-lad and it is potent and extremely visual. open and closed eye visuals are pervasive and persistent. excellent to add to less visual lsd variants

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