The Ultimate Guide to

San Pedro

(Pachanoi, Achuma/Huachuma, Aguacolla, Gigantón, El Remedio, Cactus of the Four Winds)

The Ultimate Guide to San Pedro



Disclaimer: Mescaline-containing cacti, while often legal to grow, are widely banned from human consumption. We do not encourage or condone the use of this plant where it is against the law. However, we accept that illegal drug use occurs and believe that offering responsible harm reduction information is imperative to keeping people safe. For that reason, this guide is designed to ensure the safety of those who decide to use San Pedro cactus as an entheogen or psychedelic.



San Pedro (Trichocereus/Echinopsis pachanoi) is a thin, columnar cactus native to the Andes in South America. It is much faster-growing than peyote, shooting up 12 inches or more in a year and occasionally producing large, white, night-blooming flowers.

Like peyote (and Peruvian torch, among other cacti), San Pedro contains mescaline—one of the longest-studied psychedelics in the world and the first to which that term was applied. Its effects have been described as empathogenic, (similar to MDMA) and potentially life-changing, promoting radical introspection, healing, and a sense of wonder and awe.

Traditionally, as today, San Pedro may be consumed either on its own or with other plants in a ceremonial brew called cimora. While its use as a psychedelic is technically illegal in the US, specimens are widely available for “ornamental purposes.” It can also be found in abundance at the witches’ markets of Peru (as San Pedro or Huachuma), Bolivia (as Achuma), and Ecuador (as Aguacolla or Gigantón).



There’s no way to tell simply by looking how much mescaline a cactus contains, which makes finding the right dosage quite tricky—especially given San Pedro’s variability. Just 50g dried cactus material might contain as little as 150mg mescaline (a threshold dose) or as much as 1150mg mescaline (a potential overdose).[19] So it’s best to start with the smallest dose likely to yield any effects (~7g dried; 107g fresh) and trial and error from there.[15][17] If you’re only using the outermost layer, though, the effects will likely be stronger.[7][17] One cultivar was found to contain 4.7% mescaline in the dried skins,[34] which is roughly double the whole plant “maximum” of 2.375%.

What to expect

You should start to notice effects within 15-40 minutes of taking San Pedro, but it may take 3 hours to peak. It can take another 3 hours to come down, with the whole experience usually lasting 10 hours or so[35]—although there’s usually some kind of afterglow. Residual stimulation could make it difficult to sleep after the primary effects wear off.

Many people are surprised at how different San Pedro (and mescaline generally) is from other psychedelics they’ve tried. It’s common to feel relaxed and in control, for instance, even while heavily tripping.[36][37][38][39][40] One user compared its effects to MDMA, but felt they were “more amazing.” “Mescaline didn’t feel like rolling [being high on MDMA],” he said, “Rolling felt like mescaline.” The same user went on to say that it was “like all the best effects from all the drugs all put into one… the great body feeling and incredible empathy and understanding of ecstasy… the focus and energy and drive of acid… the journey effect that I always enjoyed from shrooms… It was the soberest we had ever felt in our life.”[38]

The onset is generally accompanied by drowsiness or dizziness, often with a sense of tingling or electricity in the veins.[6][39] There may be nausea, vomiting, and perspiration during this time.[5]

Common visual effects include whirlpools of colored light, flashes in the peripheral vision, kaleidoscopic patterns, and white, ghostlike outlines around people.[5] “Out-of-body” journeys are common, according to curanderos (healers),[1][4][5][51] as is synesthesia (e.g. “feeling” and “smelling” sights and sounds), mild depersonalization, and distortions of spatial awareness.[52] At the same time, ordinary objects in your surroundings may appear more interesting, beautiful, and amazingly mystical—qualities that define the mescaline experience.[43]

Accompanying this may be clear and connected thought, self-realization, empathy, and euphoria. However, “bad trips” and dysphoric symptoms may be more common among people who don’t pay attention to set and setting and/or have histories of mental illness.[44]


Take care to remove hazards, including sharp objects and things you might trip over, before taking San Pedro. It’s also wise to ensure easy access to drinking water, as well as a toilet or bucket in case of purging. A responsible sitter is also a good idea, at least for first timers.

You may want to fast for 12 hours before using San Pedro, or at least take it on an empty stomach to minimize nausea and maximize absorption (although some claim digestion potentiates effects[1]). You may also want to spend a few hours meditating or reflecting on what you hope to learn or heal through the experience. The idea is to “purify” the body and mind/spirit in preparation for taking the medicine.[29]

Many like to experience San Pedro outdoors, in nature.[39][45] As one user put it, “the domain of this plant is space.”[37] But it’s probably a good idea to have somewhere safe and private nearby, just in case you feel overwhelmed.[40]

Optimize your microdosing efforts

Do you worry about taking too much, not measuring correctly, or losing control of your experience?

Enroll in our online microdosing course to have a safe, effective, and valuable microdosing experience.

Personal Growth


San Pedro ceremonies, traditionally held at night, are said to open the subconscious “like a flower.”[6] Some patients are more susceptible than others, of course, but it’s generally an inward journey.[5] According to Western practitioner Lesley Myburgh, the cactus “helps us to heal, to grow, to learn and awaken, and assists us in reaching higher states of consciousness.” Through her own apprenticeship, which involved twice weekly sessions for years, she “saw all the bad things in [her] life … and was able to let them go.”[29]

Others have had similar results. One user who decided to strip the wallpaper from his walls and paint his story across them was able to bring all of his pain to the surface, manifesting almost without thought his repressed struggle to be free from his mother. He was astounded by the richness of meaning, as well as his own creativity.[36]

In fact, mescaline, like other psychedelics, is well known for enhancing creativity. In one study, a group of 27 men were administered the drug and asked to think about a problem they were facing at work, some of which had persisted for months. Following this single dose of mescaline, almost every participant either solved the problem for themselves or came up with new ways to approach it.[59] As the psychologist Stanley Krippner put it, “to invent something new, one cannot be completely conditioned or imprinted,”[60] and psychedelics like mescaline certainly dissolve preconceptions and elicit fresh perspectives on reality.

Indeed, they may be so fresh that they feel otherworldly. As mentioned, “out-of-body journeys” are common, often to real-world locations—but so is a sense of induction to a “wider, mysterious, but very real [other] world that had been there all along.”[37]

San Pedro can also be helpful for strengthening interpersonal bonds or patching up family relations.[36] Its empathogenic qualities, which it shares with MDMA, instil a “sense of universal understanding, a connection with other people, and the ability to come together and work out problems”—even problems that are usually suppressed.[38] Many remark on a newfound emotional fluency, an ability to express their own emotions and identify the struggles of others.[61] It’s a sense of unity that tends to define the San Pedro experience—unity with oneself, with other people and the natural world, and with all of existence at large.[52][62][63]

Therapeutic Use


San Pedro cleansing ceremonies often last all night and may be repeated over several days. In addition to the sacred cactus, curanderos may administer other plants, including other cacti and succulents, lycopods (clubmosses), datura, brugmansia, and Isotoma/Hippobroma longiflora (aka the “Star of Bethlehem”).[5][6][47][48][49]

Ceremonies traditionally center on a “healing altar” or mesa, upon which are arranged a selection of “power objects”—ancient artifacts, staffs, stones, crosses, images of saints, and so on. These are usually sorted into three zones or fields (campos) according to their energy alignment—positive (life-giving), negative (death-taking), or neutral.[5][47][50] Following purification with a bath of “spiritual flowering” or baño de florecimiento, and often the insufflation of tobacco, patients given San Pedro are diagnosed and treated by the healer. This might involve the invocation of spirits from both Andean and Christian cosmology and the passing of a sword or staff over the patient in the form of a cross.[5][11] Sometimes a guinea pig is passed over the body instead, then killed and dissected to determine the activity or source of an illness.[11][47]

Whatever takes place in the ceremony, it is to the plant, as opposed to the healer or shaman, that cures are generally attributed. The healer is merely a facilitator, “activated” by the cactus to stimulate “the five senses of the patient in a familiar cultural environment” using music, perfumes, symbols, and other ritual elements.[5] The traditional ceremony also makes little distinction between the domains of the body and mind. Shamans may recognize the medical causes of disease, and even integrate pharmaceuticals into practice, but they’ll generally look beyond for an underlying spiritual basis.[5][35][48] Contemporary practitioners tend to frame this in psychosomatic terms, viewing “illness as a thoughtform” and the “guidance of the plant” as helping patients “to see the origin of [their] own illness without judgements or interpretations from others.”[29][41]

There are some bold claims made about the curative powers of San Pedro, but unfortunately the evidence is anecdotal. One woman, a cancer patient, is said to have entrusted her fate to the plant and, during the ritual, learned why she had cancer and that she had a choice not to have it anymore. According to the healer, “she decided not to have cancer anymore … [she] realized that life was just too precious once she had seen it through San Pedro’s eyes.”[29]

Recoveries from mood disorders are easier to believe. The same healer claims to have seen victims of sexual abuse overcome their guilt or shame, for instance, by replacing hurtful ideas or “negative winds” with “positive winds” or new insights.[29] As a legal psychedelic in many countries, San Pedro may represent a life-saving alternative to banned substances like psilocybin or LSD—sometimes the only ray of hope for treatment-resistant depression.[42]

In the 1950s and ’60s, mescaline was investigated for its psychotherapeutic potential, particularly in combination with LSD. It was found by some researchers that benefits were correlated with subjects’ willingness to engage with the experience, to face themselves and to act upon the insights received. Interestingly, some of the most significant transformations or breakthroughs came about months after the experience itself, even if the initial psychedelic therapy session seemed to be a failure. Benefits included a greater sense of wellbeing, inner strength, and vitality.[53]

Mescaline, and by extension San Pedro, may also be useful for reliving or recalling repressed memories in a psychotherapeutic context, overcoming addiction,[54][55][56][57] and dealing with chronic pain.[58]



Although mescaline is listed in Schedule I of the UN Convention on Psychotropic Substances and therefore internationally controlled, natural sources are not.[66] Often where peyote is illegal for human consumption, it is perfectly legal to grow.[79]

Where is San Pedro legal?

The following information may not always reflect the latest developments, but we’ll endeavor to keep it up to date. It is only intended to cover the personal, non-medical possession and use of San Pedro.

Countries where San Pedro is legal

To the best of our knowledge, San Pedro is currently legal in:

Countries where San Pedro is decriminalized

There appears to be no risk of a criminal penalty for the personal (i.e. “small” quantity) possession or use of San Pedro in:

Important: Decriminalization isn’t a free pass to use San Pedro however you want. The specifics depend on the country or region and, crucially, on the amount you have in your possession. Confiscation is common, but there may be other, more severe non-criminal outcomes such as fines, driving license suspension, and deportation.

Countries where San Pedro is illegal

Although San Pedro is illegal or controlled in each of these countries, there may be regional or circumstantial (e.g. religious) exceptions, as noted below:

Countries where the law is unclear

Countries that appear to have legislated neither for nor against San Pedro, or where enforcement is unclear, include:

  • Canada (prosecution seems unlikely given peyote exemption from mescaline ban)[65]
  • Ireland[64]
  • United States[78]

Optimize your microdosing efforts

Do you worry about taking too much, not measuring correctly, or losing control of your experience?

Enroll in our online microdosing course to have a safe, effective, and valuable microdosing experience.



San Pedro contains highly variable concentrations of mescaline (0.006-0.14% fresh; 0.1-2.375% dried),[1][6][13][15][16][17] densest in the outermost, greenest layer of the flesh.[18][19] As a phenethylamine, mescaline (like MDMA, 2-CB, and others) is in a different class of psychedelics to the tryptamines (e.g. psilocybin, DMT) and ergolines (e.g. LSD, LSA). The cactus also contains hordenine, anhalonidine, anhalonine, trichocerine, tyramine, and several substituted phenethylamines besides mescaline.[13][18] While their effects are thought to be secondary or negligible compared to mescaline’s, they may account for some of San Pedro’s purported medicinal benefits. Hordenine, for example, is an antibiotic, and anhalonidine has a mildly sedative effect.[7]

Receptor binding

Mescaline binds to virtually all serotonin receptors in the brain but has a stronger affinity for the 1A and 2A/B/C receptors. It is structurally similar to LSD and often used as a benchmark hallucinogen when comparing psychedelics.

Like nearly all hallucinogens, the psychedelic effects of mescaline are likely due to its action on serotonin 2A receptors.[20]

Mescaline also has an affinity for the dopamine receptors,[21] either as a selective reuptake inhibitor or as a dopamine receptor agonist.

Safety and toxicity

Because it’s an internationally controlled substance, research into the harm potential of mescaline, especially long-term, has been limited. That said, a lethal dose has never been identified—probably because it would be too high to happen accidentally.[22] In other words, to the best of our knowledge, nobody has ever died from a mescaline overdose. But that doesn’t mean it’s entirely safe; the “maximum safe dose” is often given as 1000 mg (though it’s unclear where that figure came from).[23]

A 2005 study into the ceremonial use of peyote among Native American populations found there to be no detrimental long-term effects.[24] It should be noted, however, that its use in other contexts may not be as safe (remember: set and setting). However, mescaline appears to present little risk of flashbacks or hallucinogen persisting perception disorder (HPPD).[26] Mescaline has been linked to memory and problem-solving impairments in rats, but only at very high doses (30 mg/kg/day).[27][28]

Most mescaline goes straight to the liver, so it may not be safe if you have liver problems (although it was given to many chronic, often severely liver-diseased alcoholics in the 1950s and ’60s without any obvious complications).[7] People with colon problems, high blood pressure, heart conditions, diabetes, or mental illness are also advised to be cautious.[29][30] Although peyote is traditionally consumed by Huichol women during pregnancy,[31] mescaline has been linked to fetal abnormalities and should also be avoided by pregnant or breastfeeding women.[32]

San Pedro may not be safe in combination with MAOIs (natural or synthetic), including the antidepressants phenelzine (Nardil) and tranylcypromine (Parnate). Some use MAOIs like moclobemide (Amira, Aurorix, Clobemix, Depnil, Manerix) to enhance the effects or prevent nausea but they may not be safe for everyone’s biochemistry. In fact, MAOIs may actually increase nausea, or induce it when it wouldn’t otherwise be present.[33]

Non-MAOI (e.g. SSRI) antidepressants may diminish the psychoactive effects, but they do not appear to be physically dangerous in combination with San Pedro.[30]

See FAQ for more on potential drug interactions.

History & Stats


San Pedro has been called the materia prima,[1] the primordial soup of the cosmos, and has long been revered by Andean shamans. Remnants of rolled-up San Pedro skins discovered in Peru date their use back to c. 2200 BCE.[2] Later artifacts, including temple stone carvings, textiles, and ceramics, suggest the cactus was in use by successive pre-Columbian cultures, including Cupisnique (1500 BCE), Chavín (1000 BCE), Moche (100-750 AD), and Lambayeque (750-1350 AD).[1][2][3][4][5][6][7][8][9][10] Many of these artifacts associate the sacred cactus with the jaguar, hummingbird, deer, boa, owl, snail, and stylized spirals or steps[4] — symbols thought to represent aspects of the visionary experience itself.

Its magico-religious and medicinal use was suppressed by the Catholic conquistadors,[4][6][11] but not nearly as much as peyote’s. Its early association with Christian symbols and holidays appears to have helped; in fact, it may have been strategic. San Pedro curanderismo (folk healing) ceremonies were held on June 24th, the Nativity of Saint John the Baptist,[10] for example, while the name of the plant itself, San Pedro, Spanish for Saint Peter, is thought to imply that, like the Christian saint, the cactus “holds the keys to heaven.”[1][6] But this foreign context was superimposed onto existing, pre-Hispanic/pre-Columbian ideas. Like Saints Peter and John, San Pedro had long been associated with water,[1] albeit more specifically with the fertility of Pachamama (the ‘earth mother’) and mystical “flows between worlds.” Hence the Ecuadorian name, aguacolla, is thought to have originated with the Spanish word agua (water) and Quechua word colla (queen), or else with another Quechua term denoting something hidden or occult—a “hidden water,” in other words, or a portal to “another world.”[4]

Disembodied travel is a hallmark of traditional use. Some even speculate that the Nazca Lines, the geoglyphs of southern Peru, were used as “sacred maps” for these flights.[1] Wind (symbolized by remolinos, or swirls) is also important to San Pedro, and may be seen as a portent of good health during ceremonies, or as the arrival of the spirit of the plant. This spirit is said to assume various forms when manifesting from the air in this way, including a gringo with blond hair, an Inca prince or princess, an animal (such as a jaguar), or San Pedro/Saint Peter himself.[4]

Prior to the (re-)discovery of San Pedro in 1945, botanists were unaware of any mescaline-containing cacti besides peyote. Although it was found to contain less of the psychedelic compound than peyote (<2% by dry weight[12] and 0.12% fresh[7]), San Pedro still represented a significant alternative source. Yet when mescaline and peyote were banned in the United States in 1970 (with users facing up to 15 years in jail and/or a $25,000 fine),[7] San Pedro appears to have escaped the lawmakers’ notice. People freely went on selling it as a “natural and legal” psychedelic and even mainstream garden centers continued to stock the plant.[13]

Nowadays San Pedro is used more or less as it (evidently) always has been, for spiritual and physical healing. Anthropologists and ethnographers familiar with its cultural context have helped to promote it worldwide.[4]

Current use

San Pedro is widely available in the West, but it’s often technically illegal for consumption (see Legality for details). Those who prefer to experience the plant in its native habitat can attend a growing number of specialist ceremonies and retreats in South America.

Fortunately, San Pedro populations in the wild appear to be surviving this increased demand, unlike some other natural medicines (e.g. peyote, kambo)perhaps because it grows back so rapidly when cut.[1] However, indiscriminate overharvesting in some “psychedelic tourism” regions may prove unsustainable in the long term, especially in the absence of peyote.[4][11][14]



“Peruvian torch cactus has 10 times the mescaline of San Pedro”

Adam Gottlieb made this claim in Peyote and Other Psychoactive Cacti (1977), but without any supporting evidence. In Pharmacotheon (1993), Jonathan Ott made a similar claim—that Peruvian torch has the highest concentration of any Trichocereus (/Echinopsis) species—but he seems to have missed opposing evidence.[46]

There’s actually some dispute as to whether “San Pedro” refers solely to T. pachanoi or to a range of Trichocereus (/Echinopsis) species, including T. peruvianus/E. peruviana (Peruvian torch). For clarity, most uses of the term refer to T. pachanoi alone, but it’s common to find other closely related species sold as San Pedro as well.

As for which is the strongest, it appears to be T. pachanoi. Analyses of T. peruvianus have found mescaline concentrations of up to 0.817% (dried whole plant), with some finding none at all. T. pachanoi, by contrast, has been found to contain up to 2.375%. Analyses of the mescaline-rich outer flesh alone have found the difference to be even greater: 0.24-0.25% in dried Peruvian torch skins (or up to 0.5% in the subspecies Puquiensis) and up to 4.7% in T. pachanoi.[16][34]

It should be noted, however, that mescaline content varies so much in both T. pachanoi and T. peruvianus that differences within each species may sometimes be greater than the differences between them. In other words, some Peruvian torch cuttings may well have ten times the mescaline content of some San Pedro cuttings—just not as a general rule.

Optimize your microdosing efforts

Do you worry about taking too much, not measuring correctly, or losing control of your experience?

Enroll in our online microdosing course to have a safe, effective, and valuable microdosing experience.



Can it be detected in a drug test?

Mescaline can be detected in the urine for 1 to 4 days after use, but it’s not included in either standard or extended drug screens.[67] Virtually all labs require a specific test for the substance, so unless your employer is a real stickler and specifically suspects San Pedro use you should be fine.

Are there psychological risks?

If you follow the 6Ss of psychedelic use and avoid taking San Pedro if you have a personal or family history of mental health issues, there appears to be very little chance of long-term psychiatric difficulties.[26]

Of course, San Pedro can make you feel “crazy” in the short term (acute psychosis), especially if you don’t follow the 6Ss. This is known as a “bad trip” and is unlikely to cause problems in the long term. Learning to handle anxiety and paranoia when it arises will help you get through any challenging experiences.

Are there risks?

Neither San Pedro nor mescaline appear to have caused any deaths—not by their physical action, anyway. As with any psychedelic, risks may arise from a poorly planned set and setting, e.g. hazardous environments, being in public, etc. It may also cause problems for users with mental illness, heart conditions, high blood pressure, and liver issues, as well as pregnant or breastfeeding women. For more information on using San Pedro safely, see the Safety and Toxicity section.

How do I take it?

San Pedro is best taken on an empty stomach as a brew,[35] juice,[17] or dried powder[68] (i.e. in capsules or stirred into water). Expect it to taste bitter, though—perhaps unbearably so. Chasing it down with fruit juice (especially unsweetened grapefruit juice[35]) may help; but folk wisdom holds that “if one’s heart is pure, the bitterness will not be tasted.”[69] In other words, if you’re mindful of the bitterness, experiencing it without resistance, the gag reflex shouldn’t kick in.

Is it legal to grow San Pedro at home?

It’s legal to grow San Pedro in most countries, including the US and UK, but often not for human consumption (see Legality). It’s also very easy to grow from cuttings and can thrive in a variety of conditions—both indoors and out—although it prefers a lot more water than most cacti.[70] You can even graft fresh cuttings together (including cuttings from other species) by securing them for a few days with string.[1] Just be aware, if you’re growing San Pedro for mescaline, that the common horticultural form of T. pachanoi (aka “pachanot”) has little to none of the compound.[16] See here for more info.

Can I microdose with San Pedro?

Yes! See our Essential Guide to Microdosing Mescaline.

Will it produce tolerance?

Tolerance to mescaline builds up almost immediately and takes roughly 7 days of abstinence to return to baseline. There is also a cross-tolerance effect with LSD and other psychedelics. This means they will have diminished effects for up to 7 days after your consumption of mescaline, and vice versa.[44]

Generally, though, mescaline isn’t habit-forming and many find their desire to use it actually diminishes with use over time.

Can I mix it with other drugs?

Avoid combining San Pedro with blood pressure medications, tramadol, immunomodulators, alcohol, and stimulants like cocaine and amphetamines.[32][71]

Anecdotally, people have reported good experiences mixing San Pedro with LSD[1] or cannabis,[39] among other psychoactive drugs. It also appears to be low risk or positively synergistic with psilocybin, DMT, and ketamine. Tripsit has more information on safe drug combinations.

However, it’s always best to err on the side of caution and avoid combining mescaline with any other drug, including prescribed medications (if sensible), at least the first time you take it.


[1] Rätsch, C. (2005). The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications. Rochester, VT: Inner Traditions/Bear.

[2] Johnson, C. (2018). Magic Medicine. Beverly, MA: Fair Winds Press.

[3] Carod-Artal, F.J., Vázquez-Cabrera, C.B. (2006). [Mescaline and the San Pedro cactus ritual: archaeological and ethnographic evidence in northern Peru]. Revista de neurologia, 42(8):489-98.

[4] Glass-Coffin, B. (2010). Shamanism and San Pedro through Time: Some Notes on the Archaeology, History, and Continued Use of an Entheogen in Northern Peru. Anthropology of Consciousness, 21(1):58-82.

[5] Sharon, D. (1972). The San Pedro Cactus in Peruvian Folk Healing. In Furst, P.T. (Ed.), Flesh of the Gods: The Ritual Use of Hallucinogens (pp.114-135). New York, NY: Praeger Publishers.

[6] Schultes, R.E., Hofmann, A., Rätsch, C. (2001). Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers. Rochester, VT: Healing Arts Press.

[7] Stafford, P. (1992). Psychedelics Encyclopedia (3rd ed.). Berkeley, CA: Ronin Publishing.

[8] Cordy-Collins, A. (1982). Psychoactive Painted Peruvian Plants: The Shamanism Textile. Journal of Ethnobiology, 2(2):144-153.

[9] Sharon, D. (2001). Ethnoarchaeological evidence for San Pedro (Trichocereus pachanoi) use in northern Peru. Eleusis, 5:13-59.

[10] Sharon, D. (2000). Shamanism & the Sacred Cactus: Ethnoarchaeological Evidence for San Pedro Use in Northern Peru. San Diego, CA: San Diego Museum of Man.

[11] Bussmann, R.W., Sharon, D. (2006). Traditional medicinal plant use in Northern Peru: tracking two thousand years of healing culture. Journal of Ethnobiology and Ethnomedicine, 2:47.

[12] Trenary, K. History Of Mescaline. Retrieved from

[13] Crosby, D.M., McLaughlin, J.L. (1973). Cactus Alkaloids. XIX. Crystallization of Mescaline HCl and 3-Methoxytyramine HCl from Trichocereus pachanoi. Lloydia, 36(4):416-418.

[14] Downer, C.C. (2006, Feb 6). INSIGHTS: Mining Peru’s Andean Forests Puts Unique Species, Ecosystem at Risk. Retrieved from

[15] Barton, S. (1994, Sep). San Pedro Potency FAQ. Retrieved from

[16] Trout, K. (2014). Cactus Chemistry By Species. Mydriatic Productions.

[17] Erowid. (2015, Feb 20). San Pedro Dosage Discussion. Retrieved from

[18] Erowid. (2015, Feb 10). Visionary Cactus Guide — Tricocereus. Retrieved from

[19] Ask Erowid. (2002, Feb 25). Is it true that only some parts of a San Pedro cactus contain Mescaline? Retrieved from

[20] Kovacic, P., Somanathan, R. (2009). Novel, unifying mechanism for mescaline in the central nervous system. Oxidative Medicine and Cellular Longevity, 2(4):181-190. doi:10.4161/oxim.2.4.9380.

[21] Ferri, S., Arrigo Reina, R., Spadaro, C., Braga, P. (1977). 6-Hydroxydopamine Inhibits Some Effects of Mescaline Centrally Administered to Rabbits. Psychopharmacology, 55:147-149.

[22] Ask Erowid. (2001, Mar 8). Can mescaline kill? Retrieved from

[23] Brown, R.E. (1973). The Psychedelic Guide to the Preparation of the Eucharist. Austin, TX: Linga Sharira Incense Co.

[24] Halpern, J.H., Sherwood, A.R., Hudson, J.I., Yurgelun-Todd, D., Pope, H.G. Jr. (2005). Psychological and cognitive effects of long-term peyote use among Native Americans. Biological Psychiatry, 58(8):624-31. doi:10.1016/j.biopsych.2005.06.038.

[26] Halpern, J.H., Pope, H.G. Jr. (2003). Hallucinogen persisting perception disorder: What do we know after 50 years? Drug and Alcohol Dependence, 69(2):109-19. doi:10.1016/S0376-8716(02)00306-X.

[27] Koupilová, M., Henrink, J., Krs, O. (1999). Influencing of spatial memory in rats by DSP-4 and mescaline. Acta Medica (Hradec Kralove), 42(2):69-72.

[28] Molinengo, L., Cassone, M.C., Baroli, A., Orsetti, M. (1986). Mescaline action on “memory decay” and “problem solving” behavior in the rat. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 10(6):709-15.

[29] Heaven, R. (2015, Feb 10). San Pedro, The Miracle Healer. Retrieved from

[30] steppingintofreedom. San Pedro (Huachuma) and prescribed medication. Retrieved from

[31] Meyer, S. (2011, May 24). Should I Use Peyote If I Am Pregnant or Breastfeeding? Retrieved from

[32] Natural Standard. (2011). Peyote. Retrieved from

[33] Ask Erowid. (2007, Aug 3). Are MAOIs dangerous in combination with some Trichocereus cacti? Retrieved from

[34] Ogunbodede, O., McCombs, D., Trout, K., Daley, P., Terry, M. (2010). New mescaline concentrations from 14 taxa/cultivars of Echinopsis spp. (Cactaceae) (“San Pedro”) and their relevance to shamanic practice. Journal of Ethnopharmacology, 131(2):356-362.

[35] Pachanoi, T. (2015, Feb 10). A Psychedelic Catalyst for Healing. Retrieved from

[36] Psilocybe. (2003, Aug 22). IN The Art: An Experience with Cacti – T. pachanoi (exp26305). Retrieved from

[37] Antun. (2017, Mar 15). The Domain of This Plant Is Space: An Experience with Cacti – T. pachanoi (exp109945). Retrieved from

[38] SlipKnot420. (2004, Dec 3). Let’s Spend a Lifetime Here: An Experience with Cacti – T. pachanoi (exp37131). Retrieved from

[39] Peaceful_Tripper420. (2007, Mar 17). Tranquil Visions in the Heart of Nature: An Experience with Cacti – T. pachanoi (exp42192). Retrieved from

[40] Look to the Sky. (2017, Jul 9). War Amongst the Clouds: An Experience with Cacti – San Pedro (exp100145). Retrieved from

[41] Sharon, D. (1978). Wizard of the Four Winds: A Shaman’s Story. New York, NY: Free Press.

[42] Oneiromancer. (2009, Nov 27). A War on Hell: An Experience with Cacti – T. pachanoi (exp79308). Retrieved from

[43] Smythies, J.R. (1953). The Mescaline Phenomena. The British Journal for the Philosophy of Science, 3(12):339-347. doi:10.1093/bjps/III.12.339.

[44] PsychonautWiki. (2018, Feb 21). Mescaline. Retrieved from

[45] Garuda444. (2017, Jan 6). Spirit Animal Communion: An Experience with Cacti – T. pachanoi (exp96587). Retrieved from

[46] Erowid, F. (2001). A Look at the Mescaline Content of T. peruvianus and T. pachanoi. Erowid Extracts, 2:20-21. Retrieved from

[47] Dobkin, M. (1969). Folk Curing With a Psychedelic Cactus in the North Coast of Peru. International Journal of Social Psychiatry, 15(1):23-32. doi:10.1177/002076406901500102.

[48] Dobkin, M. (1968). Trichocereus pachanoi—A Mescaline Cactus Used in Folk Healing in Peru. Economic Botany, 22(2):191-194.

[49] Davis, E.W. (1983). Sacred Plants of the San Pedro Cult. Botanical Museum Leaflets, 29(4):367-383.

[50] Erowid. (2015, Feb 10). Peruvian San Pedro Use. Retrieved from

[51] Heaven, R. (2009). The Hummingbird’s Journey to God: Perspectives on San Pedro, the Cactus of Vision & Andean Soul Healing Methods. Winchester, UK: O Books.

[52] Anopseudonym. (2010, Apr 7). Metamorphosis: An Experience with Cacti – T. pachanoi (exp78714).

[53] Sherwood, J.N., Stolaroff, M.J., Harman, W.W. (1962). The Psychedelic Experience—A New Concept in Psychotherapy. Journal of Neuropsychiatry, 4:69-80.

[54] Martin, D. (2004, Feb 22). Humphry Osmond, 86, Who Sought Medicinal Value in Psychedelic Drugs, Dies. Retrieved from

[55] Winkelman, M.J. (2015). Psychedelics as Medicines for Substance Abuse Rehabilitation: Evaluating Treatments with LSD, Peyote, Ibogaine and Ayahuasca. Current Drug Abuse Reviews, 7(2):101-16. doi:10.2174/1874473708666150107120011.

[56] Pacific Standard Staff. (2016, Oct 10). What’s behind the myth of Native American alcoholism? Retrieved from

[57] Horgan, J. (2009, Jan 12). Curing Drug and Alcohol Addiction with Peyote. Retrieved from

[58] Ferri, S., Santagostino, A., Braga, P.C. (1976). Development of Tolerance to the Antinociceptive Effect of Mescaline Intraventricularly Administered to Rabbits. Psychopharmacology, 47:261-265.

[59] Smith, P. The Diverging Mind. Retrieved from

[60] Krippner, S. (1969). Mescaline, Psilocybin, and Creative Artists. Retrieved from

[61] a soul. (2005, Jul 26). Enlightenment: An Experience with Cacti – T. pachanoi (exp40970). Retrieved from

[62] Han Solo. (2007, Jan 11). In the Embrace of Pachamama: An Experience with Cacti – T. pachanoi (exp50479). Retrieved from

[63] Visionary. (2007, Apr 12). A Message from the Plant: An Experience with Cacti – T. pachanoi & Meditation (exp56932). Retrieved from

[64] Erowid. (2016, Sep 15). Mescaline-containing Cacti – Legal Status. Retrieved from

[65] Controlled Drugs and Substances Act (S. C. 1996, c. 19). Schedule III. Retrieved from

[66] MAPS. (2001, Mar 31). DMT — UN report. Retrieved from

[67] Erowid. (2015, Feb 10). Mescaline – Drug Testing. Retrieved from

[68] Erowid. (2015, Feb 10). Usenet posts on Mescaline Containing Cacti. Retrieved from

[69] Gottlieb, A. (1997). Peyote and Other Psychoactive Cacti. Berkeley, CA: Ronin Publishing.

[70] AlbertKLloyd. (2014, Jan 13). correcting san pedro myths (work in progress) [Online forum comment]. Message posted to

[71] Therapeutic Research Faculty. (2009). PEYOTE: Uses, Side Effects, Interactions and Warnings – WebMD. Retrieved from

[72] AP. (2019, Jun 5). The Latest: Oakland 2nd US city to legalize magic mushrooms. Retrieved from

[73] Decriminalize Nature Oakland. Resolution. Retrieved from

[74] (2019, Dec 20). – A historic day for Norwegian drug policy. Retrieved from

[75] Santa Cruz Sentinel. (2020, Jan 29). Santa Cruz decriminalizes natural psychedelics. Retrieved from

[76] (2011, May 31). Bekendtgørelse om euforiserende stoffer [Executive order on euphoric substances]. Retrieved from

[77] Psychoactive Substances Act 2016 [UK]. Retrieved from

[78] DEA. (2020, Feb 21). Controlled Substances – Alphabetical Order. Retrieved from

[79] DrugWise. Cacti. Retrieved from

[80] (2020, Mar 7). Opium law. Retrieved from

[81] The Legislation of Ukraine. (2012). NOTE OF May 23, 2012 N 408 Kiev – On amendments to the list of drugs, psychotropic substances and precursors. Retrieved from

[82] TalkingDrugs. (2020). Drug Decriminalisation Across the World. Retrieved from

[83] Lovdata. Not available: Drugs Regulations, etc. (Drug List). Retrieved from

Always know what’s happening in psychedelics

We'll send you selections of our most popular content, plus updates on research, live events, new articles, free educational resources and exclusive discounts.

Reader Interactions


  1. AvatarMercules says

    I’m not sure the place you are getting your info, however good topic.
    I must spend a while finding out more or understanding more.
    Thank you for magnificent info I used to be looking for this info for my mission.