Moderate doses of psychedelics have been shown to effectively treat depressionanxietyPTSD, and other mental health conditions – and even microdoses have been reported to hold significant benefit. Although we don’t recommend it, many people are turning to psychedelics as a form of self-treatment for mental health conditions. And this brings up the potential problem of antidepressant medication interfering with the effects of psychedelics.

Unfortunately there has been no solid research performed on the interaction between psychedelics and antidepressants. Therefore most of the advice we provide here is based on anecdotal evidence and case reports. We recommend discussing issues with your physician before making any decisions.

 

THE CLASSIC PSYCHEDELICS (LSD, PSILOCYBIN, DMT)

The classic psychedelics (including LSDpsilocybin and DMT) work by affecting the serotonin system, and most antidepressants work by targeting serotonin signaling too. Therefore we’d expect for there to be some kind of interaction between the two – unfortunately we just don’t know anything for sure right now.

From anecdotal reports, it looks as if the SSRI class of antidepressants weakens the effects of classic psychedelics – although this absolutely doesn’t mean you should take more of the psychedelic substance to compensate.

Many people advise against taking Lithium or other tricyclics with classic psychedelics, as they have been known to put people into comatose states or induce seizuresAvoid this combination until we know for sure about its safety!

MAOI medications appear to have effects similar to SSRIs when combined with classic psychedelics.

Since we know so little about how classic psychedelics and antidepressants interact, we advise against taking them together. Don’t risk making things worse for yourself. If you are absolutely determined to try a psychedelic, it may be wise to wean yourself off your medication first – but always check with your physician.

 

PHENETHYLAMINE-LIKE PSYCHEDELICS (MDMA, MESCALINE)

Anecdotal reports suggest that taking MDMA while on antidepressants can either numb the effects, completely abolish the effects, or cause a really unpleasant hangover! Since SSRIs mess with your serotonin system, and bind to some of the same targets as MDMA, there is the potential for unpleasant interactions. Dr Ben Sessa, an MDMA researcher, says “The general rule is don’t combine SSRIs with MDMA.”

Taking MDMA while on MAOIs is also potentially dangerous. It’s definitely best to avoid this combination, as it could lead to serotonin syndrome (which can be fatal!).

We don’t know much about what you can combine with mescaline, but as its mode of action is similar to the classic psychedelics, it’s probably best to assume that it won’t combine well with antidepressants.

 

AYAHUASCA

Ayahuasca is a little more complicated than other psychedelics when it comes to antidepressants, because the psychedelic brew contains MAOIs, which can cause fatal reactions when mixed with other drugs. We advise a total purge from all substances before taking ayahuasca, to avoid the risk of the potentially fatal serotonin syndrome.

Here is a list of all substances you should absolutely avoid if you’re determined to take ayahuasca.

 

IBOGAINE

Ibogaine is another natural psychedelic with a potential risk of toxicity. Healthcare professionals recommend weaning off all medication before taking a dose of ibogaine.

Be aware that ibogaine is potentially the most dangerous psychedelic substance out there, as it can cause heart failure in seemingly safe situations. It is usually a last resort for people suffering from severe addiction.

 

SALVIA

We know nothing about interactions here – although we know that Salvia works on a very different neurotransmitter system than most antidepressants, and we haven’t heard any reports of unpleasant effects resulting from mixing Salvia with antidepressants.

 

WHAT’S THE TAKE-HOME MESSAGE?

We’re not medical doctors, and we don’t pretend to be. Unfortunately the research isn’t in place for anyone to give solid advice about mixing psychedelics with antidepressants. So be safe, be cautious, and always check with your physician before changing your drug-taking habits.

By Patrick Smith on

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  1. > it may be wise to wean yourself off your medication first – but always check with your physician.

    The physician will insist you continue consuming your pills for years.

    Instead watch videos/conferences of Irving Kirsh about SSRI’s.
    Also watch some by Robert Whitaker.

    Then you’ll know more than the physician and can take a decision on your own health.

    • Psilocybin is a naturally-occurring substance so Big Pharma can’t patent it. You must stay on SSRIs. Big Meat recommends eating lots of meat. Who is the we in “we don’t recommend..”?

    • I take a low dose of amitriptyline for sleep. Do not notice any effect regarding improving depression. I have skipped taking my anti-depressant at least a night or two in a row because if I do not take it at a certain time it does not help me sleep. How long do you think I would need to refrain from taking amitriptyline before using mushroom tea? I have use mushroom tea in the past and enjoyed it very much. I do not believe I was taking amitriptyline at that time however. Very curious to fine This out because based on my current situation with life in general, I believe I benefit greatly from it greatly from a nice mellow mushroom tea experience. I am 50 years old and help me. I do not take any other medications.

      • Hi Jacleen,

        Thank you for reaching out! Since we are not medical professionals, it would be advised that you seek guidance from your doctor regarding how long it takes for the medication to get out of your system, and to make sure that it is safe for you to refrain from the medication for that time.

        Best of luck to you! Let me know if I can answer any additional questions and I’ll do my best to help out.

        – Britt at The Third Wave

    • Can I take acid or shrooms while on Lexapo? I’m currently on 20 mgs and my physician advised against the combination since others have died while doing so , but I don’t know if that is actual research since he didn’t know that it was for sure because of the mixture.

      • I micro-dosed LSD for 30 days in 10 doses every three days as recommended by Dr. Faldiman. I am on Lexapro 20 mgs, Wellbutrin 300 mg, and Delpin (to help the previous two meds to be better absorbed). I didn’t read any material on whether I should or shouldn’t microdose. I was on vacation in a tropical area for two weeks when I began. I completed the last two weeks at home.

        This is what happened: I became more calm, my anxiety dissipated, and I felt spiritually refreshed and connected. I was more connected to my feelings and found myself journaling profound insights. I felt peace, gratefulness and a love for others.

        I’m glad I didn’t read the negatives of combining LSD with anti-depressants. If you decide to micro-dose, it’s recommended that you state three of four intentions for this 30 day experience. I became very clear about my intentions early on. Now I am implementing them as new goals in my life. Last, you have to believe and trust the process. This means letting go of fear.

      • I took mushrooms while on Lexapro without realizing mixing antidepressants with psychedelics could be dangerous. I didn’t notice any “cool” effects and about three hours in I had a nervous breakdown. That could have just been me though.

  2. I’m on two SSRIs (Lexapro and Abilify) as well as Xanax, and LSD has absolutely no effect on me after multiple attempts including those in which I’ve waited several days to a week w/out taking the Xanax and not taking the SSRIs for a few days. And you’re right: Increasing the dosage of LSD doesn’t help me feel its effects.

    • Abilfy is neither an SSRI or an anti-depressant. It is anti-psychotic, prescribed as an add-on when SSRI’s alone are not working. Also called “Major tranquilizers” the antipsychotics are strongly sedating. It’s not the least bit surprising that you experience NoEffect from psycheldelics on those two, plus Lexapro. They are effectively “blocking” the effect.

  3. I’d also recommend you watch Dr. Jordan B. Peterson speak about SSRIs, Depression, etc. before you decide to take yourself off your SSRIs. I tried once. It was hellish.

  4. I began micro-dosing this year and the outcome for me has been monumental. I take Lexapro 10 mg BUT I cut into 4 pieces so I’m barely on SSRI … I’m attempting to stop anti-depressants altogether because they have not worked during most periods of my life. I live in Ohio and in winter my SAD is unbearable. Suicidal, can’t function UNTIL I tried micro-dosing. Completely different human being. My biggest concern is continued sourcing. I’m a 47-year-old woman that by chance found a connection that will not be permanent. I also must share I was on Suboxone for 11 years from Heroin abuse and getting off of Suboxone was a breeze during micro-dosing. I made hundreds of attempts lost careers and almost my life during my failed attempts. There are so many benefits we don’t know about with Psychedelics, truly the difference between life and death. Thanks for a wonderful article.

  5. I am on 4mg. of suboxone, also 90mg. cr of Prozac. will it alter any of my meds? I am very interested in trying the shrooms. what does anybody have to offer to help me!!!!

  6. You can purchase a growing kit legally for about 150.00 US Dollars, and you can purchase the spores legally for about 40 US dollars and grow your own if you have a bit of a green thumb.

  7. I have bee n wondering why after eating 35 fresh picked shrooms…….it didnt even phase me…….ive been on methadone for 15 years and 40mg of p[rozac for 30 yrs. .sadly i know the harm all this crap has done to me and i am tryuing to deal with itnow……frustrated and angry……..

  8. I have been on 0.5 mg of Clonazepam for 15 years for PNE seizures in deep sleep. My PTSD was due to being kept in a closet for the first 2 1/2 years after being artificially induced 3 weeks early. I was not touched except when I was fed, diapered and given enemas. I have read that benzos alter the GABA receptor sites. Given that I have a gut feeling that psilocybin will work. Am I crazy too?

    • I take 1 MG of Clonazepam twice a day and have taken two large doses of mushrooms and have microdosed a few times. While the large doses cause the expected effects, there was no problem regarding any kind of drug interaction.

  9. What about SAM-e? I take 600mg of SAM-e daily; I don’t take any other medications.
    Will that affect microdosing or should I wean myself off of it?
    I plan to try microdosing with Psilocybin.

  10. can anyone help me!! i took antidepressant fluoxamine around 3 months eventhough the total month of my depression is 10 months.so i think i want to stop taking antidepressant as it does not help! and start microdosing..hmm idk either can or not and if i said to my dr of course she will never allow me to microdose the ‘ “”””illegal drug”””‘. i want a guidance or it was too late??

    • Hello, you are definitely not alone in your reasons for wanting to microdose.
      Also, there are many doctors who are now comfortable to talk to their patients about psychedelics, especially after the release of Michael Pollan’s “How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence”

      The Multidisciplinary Association for Psychedelic Studies offers a list of integrative therapists, medical and mental health practitioners that are comfortable talking to their patients about psychedelics:

      https://maps.org/resources/psychedelic-integration-list

      I hope you find this information helpful!

  11. Hello! I would like to try a psilocybin retreat but I’ve been on bupropion for years. Could I safely stop taking it, temporarily, to try psilocybin?

    • As always consult your primary healthcare provider, especially with regards weaning yourself off medications, however, there is no known reason why bupropion would interact negatively with psilocybin.

      It would probably be safer to remain on your current schedule of medication and take psilocybin in addition.

      Although again, check all this with a healthcare professional before making any decisions.

      • Haya, You present your information and replies very carefully and this boosts my confidence in this organization.
        Ive been a mental health prescriber for many years and I think that the challenge will ultimately be to discern approximately how long it will take for serotonin receptors to wash out after discontinuation in order to safeguard the initiation of psychededlic treatment. Currently, the official position of Neuro-psychopharmacologists is that we just dont know exactly how these meds really work and what we teach our patients is mostly conjecture. In addition, different SSRI’s and NSRI’s and different psychedelic substances have different half-lives and washout times. Drugs like psilocybin have very short half-lives, as do venlafaxine and Lexapro and Paxil. To complicate matters, it would not be clinically advisable for a patient who has a history of psychotic or suicidal
        depressions, even if the clinician personally feels that the patient might benefit, unless that patient is under close supervision, like the currently open study at Johns Hopkins is providing.
        I am personally exploring the option of micro-dosing due to a life-threatening illness, and I also take anti-depressants, and so this is my personal quest for answers. Happily, most of the good prescribers, MD’s and NP’s are very open to helping their patients find the best ways to restore themselves. No clinician is satisfied to see a patient suffer….

  12. So I’m taking 20 mg of Prozac daily and have plans to take mushrooms this weekend. Ive

    done them in the past and had a good experience but I was not on Prozac at the time. Ive

    done some research and it says that it should only dampen the effect of the mushrooms

    and I was wondering if there was any real risk of seratonin syndrome occuring (I’ll only be

    taking 2 grams of mushrooms) Anybody have any articles or first hand experiences that

    could help me make a good decision?

  13. In my youth, 1960s and 70s, I enjoyed most of the major psychedelics. So, I am very familiar with their effects. For the past several years I been taking 60 mg of the SSRI Cymbalta. I wanted to have the psychedelic experience again in my senior years. So, I grew my own mushrooms, weighed the dosage and ate them. I was amazed that I experienced no effect at all. It was only then that I realized the Cymbalta could negate the effects of psilocybin. It just didn’t occur to me. Now I have to figure out if I want to try to wean myself off the Cymbalta. I would have thought Paul Stamets or Michael Pollan might have mentioned this interaction!

    • Did you eat the mushrooms fresh, without drying them? To properly dose you must dry them out, when they are fresh it adds far too much variance in weight. 3 grams of fresh mushrooms is not equal to 3 dried. You have to eat alot of cubensis to equate to a psychadelic 3g of dried. So it is likely you are not eating enough.

  14. Went to Amsterdam. Tried to smoke 1g of indica – no effect whatsoever. Only got my clothes soaked in awful weed scent. Ate 10gr of tampanese truffles – no effect (a very slight nausea for 15 min). All bought from popular shops.. I am on 10mg Cipralex and 25mg melitor.

  15. Okay so this is going to be a little difficult I microdose pretty much as much as I can. However kind of got the feeling I was doing it too much and now that I’m not doing it my depression has returned and my doctor wants me to go on Lexapro but I’ve never taken an antidepressant before and I’m not going to stop taking shrooms. I guess I just don’t know what to do.

  16. I am on cymbalta for neuropathic pain. I took 45 grams of fresh picked shrooms yesterday with absolutely no effect. It was to be my first trip in 50+ years. Very disappointing. Weaning myself off Cymbalta, willing to bear the pain for the sake of the experience. Anyone know how long it takes for the blocking effect to subside? I figure a month, analogous to waiting a month between trips, but if anyone has experience with this I’d love to hear.

    • Im on cymbalta, antidepressive medication. When I took mushrooms had a complete blackout of the experience afterwards, so I don’t recommend takings mushrooms on cymbalta, but the interesting thing is that it does not occur any blackout when I have been taking LSD (150 mic).

  17. Started microdosing the beginning of this month without checking about the reactions with Desvenlafaxine, which I’ve been on for about two years after decades on Prozac. I am 64 and this is my first experience with these substances.

    No noticeable effects on 0.5 gm P. cubensis (dried) nor on doses up to 2 gms.

    It seems Desvenlafaxine (Pristiq) blocks the effects, as might be expected.

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