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By Patrick Smith on

Right now, millions of people are suffering from post-traumatic stress disorder (PTSD) worldwide. Up to 14% of the population of the US will suffer from PTSD in their lifetime. PTSD can develop after any kind of trauma, most commonly sexual assault or combat experience. People with PTSD may find it hard to function normally, re-experiencing their trauma in frequent waking nightmares. It can lead to depression, drug abuse, and even suicide in many cases.

SSRIs (Selective Serotonin Reuptake Inhibitors) and benzodiazepines are the most commonly used medications, but benzodiazepines do not have evidence to support their efficacy, and SSRIs only have moderate efficacy. In fact, one meta-analysis has found that 10 patients need to be treated with SSRIs for 11 weeks before a single patient will respond to treatment. Many PTSD patients who are resistant to these therapies often develop a chronic form of the disorder.

MDMA AND PTSD

The psychedelic MDMA, or ecstasy, is most commonly known for its use as a party drug. But MDMA was originally used as a tool for psychotherapy in the 70s and 80s. Psychotherapists used MDMA to induce an easily controllable emotional state that enhanced communication with their patients. When MDMA leaked into recreational use, authorities became aware of its existence, and it was made illegal in the US in 1985. Its use as a psychotherapeutic wonder-drug was abruptly halted.

That is, until recently. Convinced that thousands of psychotherapists had been onto something, MAPS (the Multidisciplinary Association for Psychedelic Studies) has funded investigations into MDMA’s therapeutic potential.

In their pilot study, 20 patients suffering from acute PTSD, most of them victims of sexual assault, were recruited for MDMA-assisted psychotherapy. They all had failed to respond to previous treatments and therapy, and on average had been suffering from PTSD for over 19 years.

In this double-blind, placebo-controlled experiment, subjects were given MDMA during long, thorough therapy sessions, overseen by healthcare professionals and administered by psychotherapists. After these sessions, the patients were measured for PTSD symptoms using two widely accepted tests.

As little as three days following the therapy, patients that had taken MDMA had significantly lowered PTSD scores compared to the placebo group. Amazingly, 10/12 of the patients who had been given MDMA-assisted psychotherapy no longer met PTSD criteria, meaning they were free of the disorder after many years of suffering. Three subjects, who had previously been unable to work due to the condition, were able to return to work as a result of the MDMA-assisted psychotherapy.

These results are impressive enough, regardless of long-term efficacy. However, the same group performed a long-term follow-up study and found that most of these patients (74%) had remained PTSD-free several years down the line. The authors state that these positive effects are an improvement from typical PTSD treatments, where only a small fraction of sufferers will respond to pharmacotherapy. MDMA-assisted psychotherapy also appears to be an improvement on talk therapy alone, where success rates are varied but generally small.

 

10/12 of the patients who had been given MDMA-assisted psychotherapy no longer met PTSD criteria.

As with all pilot studies, there are various flaws in the design, mostly relating to the small number of patients. MDMA is not a miracle drug. In this case, both the experimenters and the patients strongly believed that the controlled therapeutic environment was crucial to the success of the trial. Without guided, professional therapy, MDMA self-administration may not have the dramatic benefits shown in this study.

Testimonials from participants in the study are striking:

After witnessing the death of my 34 year old husband and another man in a violent accident, I was diagnosed with PTSD. I participated in the MAPS MDMA/PTSD study and it saved my life […] My PTSD kept me from grieving, which kept me from moving forward in my life, which made me want to die. I participated in the Boulder MAPS study in 2014 and I am finally experiencing the life saving progress everyone told me was possible.

My symptoms of PTSD became “treatment-resistant” after the medication and psychotherapy that the Veterans Affairs provided was ineffective. I began to search for alternative treatment methods, and that’s when I heard about the trial of MDMA-assisted psychotherapy to treat PTSD. After being accepted as a participant and receiving the treatment, I am proud to say that I am no longer on medications, I am able to more fully live my life, and my relationship with PTSD has changed completely.

I was prescribed many medications to treat my PTSD symptoms, but none of the treatments helped me […] My diagnosis developed into treatment-resistant PTSD and I began to drink extremely heavily and smoke upwards of two packs of cigarettes a day. […] I found out about the study conducted by MAPS and I applied to participate. I was accepted to the study and I saw a profound difference in my symptoms after the first treatment. After only 3 sessions of therapy with MDMA, I no longer qualified for a diagnosis of PTSD. Now that I have recovered from PTSD, I am able to lead a happy and productive life again. I can enjoy my beautiful relationship with the love of my life and my friends and family. It is my personal goal to spread awareness about research into this treatment method so that veterans and others suffering from traumatic events can also experience life without PTSD in the near future.

There are also various reports of people using MDMA self-administration to dramatic effect, although this is not recommended:

After deployment I developed a mild case [of PTSD]. The VA like to fix it by giving you disability checks in the mail…. So I took that money and bought drugs. Now three years later I can say I am a much happier person; less outbursts, better emotional control, I actually want to wake up in the morning and go to work, overall just have a better outlook. Over this time I have taken quite a bit of MDMA.

My PTSD was induced in childhood and was DID [Dissociative Identity Disorder] by the time I started MDMA at 19 […] The chemical broke down all my internal walls, made me whole. It still does to this day, but the chemical acted as a guide to integration so there’s a lot less division than there once was.

I have PTSD associated with my parents divorce and mothers subsequent drug addiction. [MDMA use] was the first time I ever felt comfortable with myself and started the process of building my self-esteem. A tremendously beneficial experience.

 

AYAHUASCA AND PTSD

Although there have been no clinical studies of other psychedelics and their potential to treat PTSD, there are dozens of reports of people experiencing healing effects from the psychedelic brew ayahuasca. The therapeutic shift in perception that ayahuasca offers could hold great promise in the treatment of PTSD.

Russ Binicki is a US combat veteran who experienced devastating PTSD symptoms after returning home from the Vietnam War. After years of unsuccessful treatment, he heard about the healing potential of ayahuasca from someone in his support group. Interested in any treatment that could help him, he travelled to Peru, where he took part in eight ayahuasca ceremonies:

I learned a lot of the reasons for my behaviors that I thought were normal, but really weren’t.

The experience allowed him to see himself from a new perspective and helped him revisit the traumatic memories of Vietnam in a positive light. He is not attending regular PTSD therapy sessions and recommends ayahuasca to any PTSD sufferer.

Richard Stroder, another US combat veteran, has also found therapeutic benefits from ayahuasca experiences. He was a victim of numerous sexual assaults in the military, which left him with severe PTSD. He found no relief in typical pharmacological treatment, and eventually traveled to Peru as part of MAPS’ program for veterans. With other veterans beside him, Richard participated in three ayahuasca ceremonies:

I was able to recall trauma and remember parts of my experiences that had previously been blocked out. I was able to process not only experiences from the military, but also from throughout my entire life and see how they synthesized into the person I had become. I felt a love and acceptance like never before. Negativity and pain lifted from my shoulders and released from my body in what felt like what I can only describe as a psychedelic baptism.

Stories like these are appearing more frequently as more veterans and victims of traumatic events discover the healing benefits of ayahuasca.

I felt a love and acceptance like never before.

 

THE FUTURE OF PSYCHIATRY?

Currently, MAPS is funding several further investigations into MDMA-assisted psychotherapy and has already received approval for Phase III clinical trials by the FDA. These promising developments mean that MAPS hopes to have MDMA approved by the FDA as a therapeutic drug by 2021.

Although taking MDMA at home may not be enough to help you work through a traumatic experience, when used in a clinical setting with a professional therapist, it could help to turn modern psychiatry on its head.

As Dr. Ben Sessa says in his TED talk, MDMA could be to psychiatry what antibiotics were to medicine. MDMA could be the key to opening up mental health disorders and treating all sorts of personal trauma. It may not be long until you can get a prescription from your doctor. Until then, if you decide to self-medicate, do so safely and sensible. MDMA can cause irreparable damage if used irresponsibly.

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Comments

  1. My son told me about this. I have adopted children who suffer from a range of mental health issues and am interested in learning more. To be honest, I am more than a little nervous about pychedelics but I am open to becoming educated about them. The little I’ve read, it does seem promising. I hope more research is done because this could truly change so many lives.

  2. I would do anything to help my son who suffers extreme PTSD, anxiety, depression, substance abuse. Hospitalized 12 times and prescribed meds that have had adverse affects, this sounds like it may be what he needs. Why isn’t this an option now? Thank you for this info. I am so on board.

    • I am the child of two narcissists. My dad was the classic narc with the dual personalities, beating my mom with his fists and every other abuse. Until this year, thirteen years after her death which I had to stay by her side every minute or he would still physically abuse her, I finally realized she didn’t love me or my older half brother. My mom used me from the minute I was born to be responsible for her and she didn’t want me because I wasn’t a boy. The only time I remember feeling love was when her obstetrician carried me around his office when I was a baby. Otherwise I was at a sitters who paid no attention to me or finally at home where I was akin to an ottoman or plant stand. No attention at all even though I asked her repeatedly to play with me. No physical or emotional love whatsoever. But children like me don’t know any different, we think that’s normal. I usually had a dog that gave me love and protection. If I ever said anything, like I didn’t want to move away from where I was born and my beloved cousin and “family” all were, the response I received from my mother was a threat to leave my dog behind. First and last time I ever said anything.

      My mom was excellent at controlling me to stay with her because like many others in my situation we only have value in taking care of others and we are what “they” have termed highly sensitive people. I thought she just loved me so much but actually she used me to take abuse from my father that was meant for her and to spend months in the hospital with her as her 24 hour a day warrior for months at a time after my dad had let her almost die before he would take her to a doctor. Sepsis and life support, had hospice stop food and insulin six months before the doctors gave her for lung cancer and came after me for calling her doctor and following his instructions to call an ambulance ASAP. I found two doctors after much research that agreed to treat her lung cancer with an oral nonaggressive chemo pill to shrink her cancer so they could use radio frequency ablation to destroy the reduced size of the cancer! My dad told her, after both sat in the doctor’s office with me while he explained everything in detail, that she was only taking the pills to add a month or two to her life. She stopped taking the pills, that were working, without telling me but did tell my favorite aunt who didn’t bother to tell me either.

      My mom died when I was forty. I had a complete break from CPTSD at 38. I was a successful executive and also sold large custom houses in the most prestige area and development in my area. Then a new shift in upper management placed me directly under a narcissist with plans for me not on any job description. The first panic attacks were at work before his abuse started. I went through every doctor imaginable including my ENT and no one diagnosed me.

      I lost everything I worked all my life to achieve. I also lost my ability to work, drive, get out of the ball I was in on the couch, and all the people I had known all my life including all family. I have fought alone against horrific doctors for fourteen years but my amazing Shih Tzu who was only a baby when this started saved my life. He literally took care of me, knew I was going down before I did and knew exactly what to do when I hit the wall. Only real family I ever had. This past year was the worst of my life, I learned how evil people are and will literally leave you to die. I went through things I could not even imagine including my dad’s death, my Great Dane’s death and Wafer’s murder. And still not one person cared if I lived or died.

      It seems like this is too long but it’s not even close to the hell I live. I am on an antidepressant, anti anxiety, sleep REM medicine and something to boost my strength. My heart rate has been close to 120 all these years. I fought for a year and a half to be included in MAPS Phase III testing and was accepted by one spot but couldn’t ever get in touch with the director again and MAPS is no help.

      I have been talking to a veteran with the most experience in the field of psychedelics begging him for help, anything including getting me in touch with people he knows in my area with experience in this area. I should add that my dad was a highly decorated Korean War soldier so I am sure part of his illness was PTSD. This I carry the wounds of hand to hand combat even if I am not a veteran.

      I have come to the end of my ability to survive. Wafer was the only soul who gave me a reason to live and fight. I have been alone all my life, except for him. And the vets who actually killed him are suing me because I refused to let them do horrid procedures on him when the agreed upon treatment was to continue the treatment for kennel cough he received in Monterey for three weeks until the vets there actually listened to me and treated him for that. And that only after my second and third dogs literally got sick right in front of them and then they tested for kennel cough!

      According to the veteran I have been in contact with, the largest number of veterans who kill themselves every day are alone, like me.

      And not one agency or organization helps. And I should have been dead years ago. When not one person in the world cares if you live or die, you learn that no one ever will and each year gets worse, what are we fighting for so desperately?

      For those of you who posted about children, my advice would be to fight as to the death to find these alternative treatments for your loved ones. I spoke to several people who went through the MAPs earlier MDMA trials and they were cured. If I knew how I would buy some MDMA as a last ditch effort. But you have to be very careful because it’s usually not pure. But I don’t know how to buy it and I don’t have any strength left to keep fighting.

      I hope this helps one person fighting alone and especially a child in the hell I lived in to get someone to do the right thing and intervene instead of turning away. I also hope it convicts people who don’t want to be bothered that they are just as responsible as anyone for not being the one friend needed to save another person’s life.

      • We’re truly sorry for the pain and suffering you’re enduring. Fortunately, there are legal psychedelic treatments available that may be of help. There’s increasing evidence suggesting that ketamine can be helpful for treatment-resistant depression, but also PTSD. Dr. Phil Wolfson is a pioneer in this space and located in Northern California. His team may be able to help: http://philwolfsonmd.com/ketamine-assisted-psychotherapy.html.

  3. I have PTSD. I have tried MDMA in the past in low doses and I still have PTSD. I didn’t use it therapeutically, however, and would be interested in trying it as such. I remember that I used speed before and noticed that while I was high on the speed, I was able to be touched without freaking out, which is a first. Unfortunately, I also noticed I would dissociate more or be more prone to dissociating during the comedown period, and, after using speed, I still suffer from PTSD symptoms while sober.
    I am sober these days, but have been interested in trying shrooms medicinally because my PTSD still actively affects my life, after 16 years +

  4. Very touched by the story above. Thank you for sharing your Journey. Have PTSD and barely hanging on. Looking to be selected for a MDMA pilot program on West Coast.

    • Hi there S.M.,

      Thank you for being a part of our community! We genuinely hope that you are able to integrate psychedelics into your life in order to working towards healing. There is so much promising research regarding MDMA and PTSD healing!

      We wish you all the best. Please keep in touch as your journey progresses.

      – Britt at The Third Wave

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