The Ultimate Guide to


(5-MEO, Five-methoxy, The Power, Toad venom)

The Ultimate Guide to 5-MeO-DMT



Disclaimer: 5-MeO-DMT is a potentially illegal substance, and we do not encourage or condone the use of this substance where it is against the law. However, we accept that illegal drug use occurs, and believe that offering responsible harm reduction information is imperative to keeping people safe. For that reason, this guide is designed to ensure the safety of those who decide to use the substance.



5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT).

In Central and South America, some of the best known 5-MeO-DMT sources are Anadenanthera peregrina (yopo or cohoba) and Virola theiodora—both of which are traditionally harvested to make psychoactive snuff. It’s also found in the milky white venom of the Colorado River Toad (Bufo alvarius/Incilius alvarius) native to the southwestern United States and northwestern Mexico.

In keeping with its ceremonial use among indigenous Amazonians, 5-MeO-DMT shows great promise in the treatment of certain medical conditions. Many people also find its effects to be personally useful or even life changing.



Vaporizing or smoking 5-MeO-DMT powder is probably the most common route of administration. The next common is snorting or insufflation.

Effects from vaporizing or smoking 5-MeO-DMT are usually felt within the first 30 seconds, peaking from 1-15 minutes and lasting for up to half an hour. A threshold dose is around 1-2 mg, while a moderate-to-strong dose is 5-10 mg.

Insufflated, it may take up to five minutes to feel the effects, despite the higher dose ranges involved (threshold: 3-5 mg; moderate: 8-15 mg). Effects tend to peak after 10-30 minutes and subside from around 30-45.[20]

5-MeO-DMT oral doses for swallowing[21] are higher, with generally unreliable results. Other less common routes of administration include sublingual (under the tongue) and injection.[22]


Effects come on strong, often with a loss of physical coordination and control. Users experience bright colors, moving environments, or recursive patterns, and perhaps even “environmental orbism” at higher doses. However, visual effects are limited. Unlike DMT, 5-MeO-DMT isn’t known for its visionary properties. The experience is more often described as a “perspective shift” characterized by physical, emotional, and conceptual effects.

One of the most common features of the 5-MeO-DMT experience is an enhancement of tactile awareness to the point of sensory overload. The body may also feel heavier. Intense emotions are typical, ranging from extreme fear to euphoria, and especially include anxiety or excitement during onset. It’s common to experience an overwhelming sense of oneness with the universe, or a sense of being outside of time and space while seeming to experience the totality of both. The concept of the ego as a separate entity is typically lost. Other effects include auditory hallucinations, time distortion, nausea, and memory loss.


Click here to listen to Ashley Booth describe her life-changing 5-MeO-DMT experience


5-MeO-DMT should not be taken with MAOIs, including some antidepressants. Combining them may cause severe hypertensive symptoms (elevated blood pressure, heart rate, and temperature), seizures, long-term kidney damage, serotonin syndrome, and death.[27]

Because of the somewhat unpredictable nature of 5-MeO-DMT, a sitter is definitely recommended. Short-term unconsciousness, respiratory depression, and delusional interactions with the environment are some of the things to watch out for.[28] At the very least, it should be taken in a comfortable seated or lying position to avoid falling over.

Those new to 5-MeO-DMT should start out with a low dose, weighed on a scale accurate to 0.002 g (2 mg). Since people tend to react differently to the same doses (and it’s not entirely clear why) caution is advisable even if you have prior experience of tryptamines.

As with any psychedelic, follow the 6Ss of psychedelic use to minimize the risks of a bad experience.

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Personal Growth


Ego loss on 5-MeO-DMT is often described in positive terms—even if the experience was terrifying at the time. Many see it as a process of death and rebirth followed by lasting self-improvements, including mental clarity, increased motivation, enhanced awareness, joy in living, and a sense of inner peace. Some have also attributed to 5-MeO-DMT enlightenment experiences characterized by a sense of inseparability from the universe or of being “all that exists.”[44][45][46] Often, these experiences come in waves or ‘reactivations’ over the following days or weeks.

Being forced to let go of the ego is precisely what draws many people to 5-MeO-DMT. The dissolution experience can impart an understanding and acceptance of mortality that helps to overcome the fear of death.[32] It can also break attachments with past trauma, negative behaviors, and habitual negative thought patterns.

One group of 5-MeO-DMT ‘practitioners’ have suggested a number of specific integration and grounding techniques to make the most of the potential for growth. These include acupuncture, massage, physical exercise, certain foods, and even just talking to others. Interestingly, they advise against meditation because it could end up prolonging the grounding/integration period by triggering additional ‘reactivations’.

Therapeutic Use


5-MeO-DMT is routinely used to alleviate depression, anxiety, PTSD, and addiction.[32][33] It’s sometimes used alongside ibogaine treatment to help patients integrate what they’ve learned.[34]

Limited clinical research appears to support such use of 5-MeO-DMT in treating addiction and depressive disorders. After administering the compound to mice, researchers found a major downregulation in mGluR5, a receptor involved in the reward mechanism of drug abuse. Not only are mice without the mGluR5 gene less likely to self-administer cocaine and ethanol, they also show less severe symptoms of nicotine withdrawal. Furthermore, cells treated with 5-MeO-DMT showed an upregulation of integrins, a response similar to that of depressed patients to antidepressant medications.[35]

5-MeO-DMT also appears to have a placebo analgesic effect comparable to hypnosis.[36][37][38] Like the other classical psychedelics, it may be useful in the treatment of acute and chronic inflammatory conditions[39][40], including some cancers.[41][42]

More indirectly, 5-MeO-DMT helps researchers to better understand the neurobiological basis of schizophrenic hallucinations—ultimately paving the way for more effective antipsychotic drugs.[43]



5-MeO-DMT has only really come to law enforcement attention over the last few decades. Some countries have specifically banned it, while others treat it as an analog of a controlled substance.

Where is 5-MeO-DMT legal?

The following information may not always reflect the latest developments, but we’ll endeavor to keep it up to date. It is only intended to cover the personal, non-medical possession and use of 5-MeO-DMT.

Countries where 5-MeO-DMT is legal

It’s unclear whether 5-MeO-DMT is technically legal in any country at present. But it doesn’t appear to be controlled in:

Countries where 5-MeO-DMT is decriminalized

There appears to be no risk of a criminal penalty for the personal (i.e. “small” quantity) possession or use of 5-MeO-DMT in:

  • United States: Oakland, CA (in plants)[74][75]; Santa Cruz, CA (in plants)[79]

Important: Decriminalization isn’t a free pass to use 5-MeO-DMT however you want. The specifics depend on the country or region and, crucially, on the amount you have in your possession. Confiscation is common, but there may be other, more severe non-criminal outcomes such as fines, driving license suspension, and deportation.

Countries where 5-MeO-DMT is illegal

Although 5-MeO-DMT is illegal or controlled in each of these countries, there may be regional or circumstantial (e.g. religious) exceptions, as noted below:

Countries where the law is unclear

Countries that appear to have legislated neither for nor against 5-MeO-DMT, or where enforcement is unclear, include:

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Like the other tryptamines, 5-MeO-DMT has the same basic indole ring structure as DMT. It is so-called for having a methoxy group in the R5 position.


5-MeO-DMT works primarily through the serotonin (5-HT) system, with a particular binding affinity for the 5-HT1A receptor subtype.[13] It also binds to 5-HT2A and trace amine receptors, possibly mediating hallucinogenic effects via the latter.[14]


There is some evidence that indolealkylamines, including 5-MeO-DMT, cause serotonin syndrome when overdosed or combined.[15] Of particular concern are possible interactions with monoamine oxidase inhibitors (MAOIs) such as harmaline or harmine.[16][17] These are sometimes combined with the drug to enhance its effect, but can dangerously increase exposure to both 5-MeO-DMT and its active metabolite bufotenine.[18]

Some other safety concerns have been flagged up by animal studies. In rats, 5-MeO-DMT was found to induce hypothermia at low doses (0.5-1 mg/kg) and hyperthermia at high doses (3-10 mg/kg). In sheep, grazing on the 5-MeO-DMT-containing Phalaris tuberose/aquatica (or bulbous canary-grass) caused fatal tachycardia and respiratory failure.[13] Although more likely due to other toxins in the plant[19], this severe reaction underscores the need for caution when approaching 5-MeO-DMT’s many and varied natural sources.

History & Stats


Traditional use of 5-MeO-DMT in the Americas goes back hundreds – maybe even thousands – of years. Ancient snuffing paraphernalia and traces of the compound found in northern Chile date the practice to at least the 8th century.[1] The use of 5-MeO-DMT-containing snuff was first recorded in 1496 by Friar Ramón Pané. Reporting to Christopher Columbus on the Taíno people of Hispaniola, Pané observed inhalation of cohoba snuff through reeds. Typically, it was used as a purgative for the sick, as well as a medium through which to obtain medical diagnoses from spirits.[2]

In 1737, Joseph Gumilla observed a similar practice, with yupa (or yopo), among the Otomac of southern Venezuela.[3] Some time later, Alexander von Humboldt described how the snuff was made. First, the seeds of the Acacia niopo (Adenanthera peregrina) were left to blacken, then mashed into a paste with cassava flour and lime from snail shells. This mixture was dried over a fire and pulverized for use—typically inhaled through a Y-shaped bone tube, such as a plover leg, with the forked ends straddling the septum.[4] Another account from Richard Spruce in the mid-1800s described the use of tubes between two people—one to blow the snuff into the nostrils of the other.[5] Spruce also collected specimens of the Adenanthera peregrina for identification.

In 1936, 5-MeO-DMT was synthesized by the chemists Toshio Hoshino and Kenya Shimodaira.[6] But it wasn’t until 1959 that it was finally identified as the major psychoactive component of yopo/cohoba.[7] It was also found in the venom of the Colorado River Toad (Bufo alvarius/Incilius alvarius or Sonoran Desert Toad), sometimes at levels of up to 15% by volume.[8]

From the early 1970s, 5-MeO-DMT could be legally ordered in the US and other countries via mail order from the Church of the Tree of Life[9] and the Church of the Toad of Light.[10] Since scales accurate to the milligram weren’t widely available, it was typically added to parsley or cannabis to help with dosing.[11]

Recreational use steadily increased over the ensuing decades while remaining underground. In the 1990s, ethnobotanist Jonathan Ott and others popularized and developed 5-MeO-DMT for sale on the internet. In 2001, research chemical vendor Mark Niemoller was arrested under the Controlled Substances Analogue Act of 1986. He was released on house arrest after agreeing to stop selling 5-MeO-DMT and a number of other substances.[12] In July 2004, “Operation Web Tryp” saw the DEA shut down five more 5-MeO-DMT and research chemical vendors, prompting numerous others to stop trading voluntarily. In January 2011, 5-MeO-DMT was declared a Schedule I drug in the United States.

Current use

5-MeO-DMT is often conflated with other tryptamines or “novel psychoactive substances” in major drug surveys, so it’s difficult to gauge its exclusive prevalence.

However, it’s possible to get a general feel for its popularity over time by looking at Google search statistics. Between 2004 (the year of “Operation Web Tryp”) and 2007, searches for 5-MeO-DMT fell dramatically and have remained at a steady low ever since.



“5-MeO-DMT is a form of DMT”

This myth is based on a common, and potentially very dangerous, misunderstanding of pharmacology. It’s no more a form of DMT than psilocybin is. Although the two substances are chemically related, the effects of 5-MeO-DMT vs DMT are substantially different–as are their safety profiles. 5-MeO-DMT, for example, has a much lower toxicity threshold than DMT, so conflating the two could be dangerous.[29]

“Licking toads in an easy way to get high.”

Alexander Shulgin attributed this myth (or rather, very bad idea) to sensationalism in the media.[30] Licking the Colorado River Toad has never been a common method for obtaining 5-MeO-DMT, for the simple reason that it’s deadly. Other chemicals in raw toad secretions are known to be cardiotoxic, which means they’ll disrupt the functioning of the heart. Numerous humans have died after licking toads and one child who was hospitalized with seizures from the venom took a week to recover.[31] Given that just this one, geographically isolated species is known to be psychoactive, there’s also the danger of licking the wrong toad entirely, which can cause death or permanent paralysis.

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Can it be detected in a drug test?

5-MeO-DMT isn’t detected in any standard or extended drug tests, nor are there specialized tests to look for it. Also, since it’s unlike other drugs tested for, it shouldn’t trigger a false positive.

Where can I buy 5-MeO-DMT online?

You can usually find 5-MeO-DMT for sale from vendors in Canada, Mexico, and other countries where it isn’t controlled. If you don’t live in one of these countries, however, it’s obviously still illegal to buy 5-MeO-DMT online from a vendor in Canada (for example) and import it.

Can I test my 5-MeO-DMT to see if it’s safe to take?

Testing your 5-MeO-DMT is always good practice even when you trust your supplier. Reagent test kits from Bunk Police can identify hundreds of adulterants and substitutes—offering peace of mind and potentially saving your life.

The Hofmann and Mecke reagents, for example, can help identify real 5-MeO-DMT. Simply place a tiny amount of 5-MeO-DMT into a sterile test tube or onto a sterile white ceramic surface and add a few drops of the reagent. Then check the color change (or lack thereof) against the supplied spectrum booklet.

Can 5-MeO-DMT cause psychological trauma?

Most people find the effects overwhelming. Consensus reality, the physical environment, body, and self tend to fall away and behavior can become irrational. While long-term psychosis seems improbable, it may take some time to fully recover from the 5-MeO-DMT experience.

After higher doses, some users have reported persistent psychological difficulties, including paranoia and the subtle (but controllable) resurfacing of effects, that can last for several weeks.[48][49][50]

“White-outs” and memory suppression are also common during the 5-MeO-DMT trip itself, negatively affecting users’ ability to form memories of the altered state.[22][24]

Are there risks?

Taken in the presence of a sitter with no other drugs or contraindicated medications (like MAOI antidepressants), 5-MeO-DMT appears to be relatively safe. That said, persistent anxiety has been reported after just one use, along with sleep disruption and panic attacks. To help minimize the risks, it’s a good idea to start with low, precisely measured doses, and have an experienced sitter present.

Alternatively, you may wish to have a more actively engaged facilitator, or ‘practitioner’, present—a 5-MeO-DMT specialist trained to guide and help integrate your experience. Click here for in-depth tips on how to choose the right person or group for the job and what you should expect them to do.

What should I do in the event of a 5-MeO-DMT overdose?

5-MeO-DMT overdose reports indicate a risk of breathing difficulties and loss of consciousness.[52][53][54] If this happens, roll the person onto their side and call the emergency services, keeping them calm until paramedics arrive. A responsible, trained sitter may also need to provide mouth-to-mouth resuscitation after checking the airway is clear.

Is it legal to cultivate natural 5-MeO-DMT sources (5-MeO-DMT plants, 5-MeO-DMT toad species, etc.)?

Cultivating plant sources of Schedule I drugs (except in specified cases like cannabis and peyote, and obviously where entheogenic/psychedelic plants are specifically decriminalized) is a bit of a legal grey area. While the law prohibits “any material containing any quantity” of illegal substances, the likelihood of prosecution is slim. On the other hand, 5-MeO-DMT extraction from any source is definitely illegal and will lead to prosecution if caught.

Regarding toads, the rules are clearer. In New Mexico, only state residents may collect them without a license. Both residents and non-residents of Arizona need a fishing license to collect a maximum of 10 Colorado River Toads. In California, meanwhile, it’s a misdemeanor to collect toads and possession is against the law. Regardless of the legality, though, the Colorado River Toad is a threatened species. Keeping toads in captivity—not to mention regular “milking”—is found to damage their health.

What’s the safest way to take it?

There is no entirely safe way, but vaporizing or smoking 5-MeO-DMT powder is by far the most tried and tested. The onset of effects is shorter than with insufflated or sublingual use, however some people experience chest pains from the smoke. Others experience no effects whatsoever and prefer intravenous or intramuscular injections. These induce rapid, intense effects even at low doses. Swallowing the drug isn’t recommended due to safety concerns and it’s often ineffective anyway.

Can I microdose with 5-MeO-DMT?

As people’s reactions vary immensely, it’s hard to give a reliable microdose range. Some have felt profound effects on less than a threshold dose, while others experience only mild effects from a moderate dose.

Can I develop a tolerance?

Yes, tolerance develops almost immediately and takes two hours to return to baseline. But there is no cross-tolerance with other psychedelics.

Can I mix it with other drugs?

It shouldn’t be mixed with MAOIs or RIMAs, including some antidepressants, due to the risk of serotonin syndrome and death. Releasing agents and reuptake inhibitors, for serotonin and dopamine especially, can be dangerous in combination. For this reason, mixing 5-MeO-DMT with other psychoactive drugs is discouraged. Combining with alcohol is strongly discouraged due to the risk of vomiting and subsequent choking.

Is 5-MeO-DMT similar to 5-MeO-MiPT, 5-MeO-DALT, 5-MeO-DiPT, etc.?

Not necessarily. Substances in the 5-MeO group may share some basic similarities, but effects and safety can vary. Dosage in particular tends to vary significantly, as does legal status—so it’s unwise to assume they’re interchangeable.

Here’s a brief overview:


5-MeO-MiPT or Moxy can be taken orally (e.g. as 5-MeO-MiPT HCl) or smoked (as freebase). Threshold effects may be felt from as little as 1-2 mg oral (or 10-15 mg 5-MeO-MiPT smoked). 15+ mg is considered strong or heavy.[55] The experience may be described as psychedelic or entactogenic (like MDMA) and has a duration of 5-8 hours.[56] Some people use 5-MeO-MiPT for sex.[57] Although it’s possible to buy 5-MeO-MiPT online in the USA, its legal status is unclear.


5-MeO-DiPT or Foxy (or Foxy methoxy) is entactogenic and sexual, similar to 5-MeO-MiPT. It’s usually taken orally as 5-MeO-DiPT HCl (3-15+ mg) and has a duration of up to 8 hours.[58][59] Although a Schedule I substance in the USA, in Canada 5-MeO-DiPT is legal.[59][60]


5-MeO-DALT is taken orally as 5-MeO-DALT HCl at a dosage of 4-30+ mg.[61][62] Like the 5-MeOs described above, it’s mildly psychedelic and often used for sex.[62][63] Apparently, it also helps alleviate cluster headaches.[64] You might find 5-MeO-DALT for sale in the USA, given that it’s unscheduled–outside of Florida, at least. But it may be considered an analogue of 5-MeO-DiPT.[62][65]


5-MeO-aMT or Alpha has a reported threshold dose of just 0.5 mg, and 6-15 mg may be heavy. Effects are said to last 8-12 hours.[66] On Erowid 5-MeO-aMT is linked to a number of hospitalizations and possible deaths following overdose (ranging from 5-50 mg).[67] But it’s reportedly unscheduled in the USA– again with the exception of Florida.[68][65]

Other 5-MeOs

  • 5-MeO-pyr-T: potentially dangerous at just 0.5-3 mg*[69]
  • 5-MeO-MALT: reportedly euphoric at 15-50 mg oral*[70]
  • 5-MeO-DET: uncomfortable drunk feeling at 1-3 mg oral*[71][72]
  • 5-MeO-TMT: sexually stimulating at 65-90 mg; nauseating at 120+ mg[73]
  • 5-MeO-BFE (aka dimemebfe)
  • 5-MeO-DiBF
  • 5-MeO-NiPT
  • 5-MeO-DPT
  • 5-MeO-NMT
  • 5-MeO-MET

* dose/effects based on limited reports and by no means definitive; included only to give a sense of the variation within the 5-MeO group of substances


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Reader Interactions


  1. Jay Houston says

    Where can i get dmt? I hear Joe Rogan talk about it on his podcasts and makes it aound kick ass.

  2. Steve Blalock says

    A cool thing to do with these posts would be a quick and easy guide to getting what you are posting about so we can experience it. Being a newbie to this all the technical and scientific talk is great, but we want to experience it.

  3. Beau Jaco says

    why wpuld they disclose info on how to purchase/obtain substances that are possibly illegal in many jurisdictions. darknet or do more research

    • Sepehr Masoudi says

      There is millions and millions of Researched Chemicals sold as Psychedelics,
      They all have a very similar infrastructure, but slightly different
      They all have the same overall effect tho
      And to trip da fuckoutta yaa

    • U. says

      @Sepher that is not true bro there are at least 4 distinctly different “Families” of hallucinogenics the most common is the psyllocibin , lsd , dmt , mescal family that are all very similar in the way they induce effect , 5 meo i would see as a (distant) kin to them , then there is Iboga / Voacanga that has a different vector more deep in than far out , then there is Salvia divinorum quite different to the aforementioned and then there is the whole nightshade group that i would not advice for mere recreation or experiment hard to do in a good way.

  4. says

    A fascinating discussion is definitely worth comment.

    I believe that you should publish more on this subject, it may
    not be a taboo subject but generally folks don’t speak about such issues.
    To the next! All the best!!

  5. jwm says

    For some reason my comment landed here on the DMT page, and not on the mescaline page. “A Vein of Fire” is an account of an Achuma (Trichocereus Bridgesii) experience. Thanks to those who have clicked.