From Placebo to Plasticity: What LSD Really Does

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Episode 327

Conor Murray, Ph.D.

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with Dr. Conor H. Murray, a neuroscientist at UCLA whose research explores how psychedelics affect the brain.

Conor shares insights from his placebo-controlled LSD microdosing study revealing measurable increases in neural complexity, suggesting unique neurological benefits even at sub-perceptual doses. He and Paul discuss what these findings mean for depression, addiction, and brain plasticity, as well as the future of citizen neuroscience through Conor’s platform Psynautics. They also touch on his ongoing psilocybin study for cocaine use disorder and why low-dose research may hold keys to understanding consciousness itself.

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Conor Murray is a neuroscientist specializing in altered states of consciousness at UCLA. He is also the founder of Psynautics, the world’s first citizen neuroscientist platform built for testing hypotheses related to altered states of mind and brain, from meditation to microdosing. His scientific expertise spans from the neurobiology of addiction to the effects of cannabis and psychedelics on the brain.

Podcast Highlights

Highlights

  • How Dr. Murray entered psychedelic research by chance
  • What LSD microdosing reveals about neural complexity
  • The “sweet spot” around 13 micrograms for mental clarity
  • Why placebo effects don’t fully explain brain changes
  • Microdosing vs macrodosing in neuroplastic outcomes
  • BDNF, inflammation, and the mechanisms of healing
  • Psilocybin’s potential for cocaine use disorder
  • How environment influences addiction and relapse
  • The rise of citizen neuroscience and DIY EEG studies
  • Where psychedelic science is headed next

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