Microsodosing LSD in the 21st Century: Set, Setting & Sustainability

From Albert Hofmann’s first synthesis to its rise in the 1960s counterculture, LSD has always moved with culture, shifting between discovery, controversy, and expanded consciousness.

Today, LSD is re-emerging in both culture and research as a living practice shaping how people think about mental health, creativity, and human potential.


Recent RAND research estimates that more than 10 million U.S. adults microdosed psychedelics in the past year. At the same time, emerging research is beginning to map LSD microdosing’s safety profile and potential across mental health applications, from depression to women’s health.


We are still early in the modern LSD era. With less than 100 years since its synthesis, we are uncovering its full potential, how to optimize microdosing approaches, how to weigh benefits and risks, and how it may fit into the future of mental health, creativity, and personal transformation.


The story is still unfolding, and we’re holding space for the conversation alongside Zach Leary, Author of Your Extraordinary Mind, host of the Psychedelics Then and Now podcast, longtime psychedelic educator, and son of Timothy Leary. 


Join the Microdosing Collective and Third Wave, alongside Zach Leary, for a live webinar and cultural deep dive into LSD microdosing in the 21st century, where science, history, and lived experience converge.